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Vascular Pathology October, 11th, 2005 Queen Mary´s School of Medicine and Dentistry The Royal London Hospital. Apoplexia cerebri. Apoplexia cerebri. Angina pectoris. Apoplexia cerebri. Angina pectoris. Claudicatio intermittens.
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Vascular PathologyOctober, 11th, 2005Queen Mary´s School of Medicine and DentistryThe Royal London Hospital
Apoplexia cerebri
Apoplexia cerebri Angina pectoris
Apoplexia cerebri Angina pectoris Claudicatio intermittens
StrokeTIA / PRIND Angina pectorisAmaurosis fugax Angina intestinalis Claudicatio intermittensChronic peripheral ischemia
1. Histology of arteries2. Vascular pathology in the daily work of a histopathologist 3. Current projects
HistologyElastic arteriesMuscular arteries Transitional arteriesCapillaries
Elastin Collagen Collagen matrix Axial Smooth muscle cells Transversal
Wolinsky H, Glagov S: A lamellar unit of aortic medial structure and function in Mammals. Circ res 1967; 20: 99-111
Concept of transitional arteriesThe transitional zone is a segment of the arterial tree, where elastic-type wall architecture is relayed by one of muscular type. Transitional arteries are characterized by a different ratio of scleroproteins (elastin,collagen) and vascular smooth muscle cells in the tunica media (Janzen 2004).
Arterial transitional zone • (Vuong und Janzen 1995) • Janzen J: Die arterielle Übergangszone. Perfusion 2004, 17: Supplement 1 • Janzen J: The microscopic transitional zone between elastic and muscular arteries. Arch Mal Coeur Vaiss 2004, 97: 909-914. • Janzen J: Beeinflusst die Übergangszone die Atherosklerose? Vortrag, 18. Jahrestagung Deutsche Gesellschaft für Arterioskleroseforschung. Ulm-Blaubeuren 11. März 2004 • Janzen J, Lanzer P, Vuong PN: Atherosklerose und die Übergangszonen arterieller Blutgefässe. Präsentation, 16. Jahrestagung Deutsche Gesellschaft für Arterioskleroseforschung Ulm-Blaubeuren 7. März 2002 • Vuong PN, Berry C: The pathology of vessels. Springer-Verlag France 2002, Paris, 1-25 • Janzen J, Lanzer P, Rothenberger-Janzen K, Vuong PN: Variable extension of the transitional zone in the medial structure of carotid artery tripod. Vasa 2001; 30: 101-106 • Janzen J, Lanzer P, Vuong PN: Die Übergangszone in der Nierenarterie und Karotisgabel. Perfusion 2001; 2.90 • Vuong PN, Janzen J, Lanzer P: Fatal myocardial infarction in a young man caused by a right megadolicho-coronary artery with thrombosis: a case report. Z Kardiol 2001; 90: 1-5 • Janzen J, Lanzer P, Rothenberger-Janzen K, Vuong PN: The transitional zone in the tunica media of renal arteries has a maximal length of 10 millimetres. Vasa 2000; 29: 168-172