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When Do Isotypes Matter?

When Do Isotypes Matter?. The primary -> secondary immune response: Increase Ig titer Switch from IgM to IgG Increase Ag binding affinity. Where and when do affinity maturations and isotype class switch occur??. BCR:mIgM. mIgG. sIgG. CSR/SHM. Infection and Ag presentation.

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When Do Isotypes Matter?

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  1. When Do Isotypes Matter? • The primary -> secondary • immune response: • Increase Ig titer • Switch from IgM to IgG • Increase Ag binding affinity

  2. Where and when do affinity maturations and isotype class switch occur?? BCR:mIgM mIgG sIgG CSR/SHM

  3. Infection and Ag presentation

  4. Infection and Ag presentation

  5. Infection and Ag presentation

  6. Generation of plasmablasts in the spleen Red pulp border T cell zone B cell zone

  7. T cells: CD4+ and CD8+ CD4+ CD8+

  8. APCs: present Ag in the context of MHC class II to T helper cells

  9. Ag presentation to T helper cells in the spleen

  10. T helper cells are CD4+ • are activated by APC • secrete cytokines to • augment the immune • response

  11. T helper cells polarize into TH1 and TH2 cells and secrete unique combinations of cytokines

  12. Cytokines target germline transcripts to specific Ig isotypes in B cells

  13. Cytokines target germline transcripts to specific isotypes g3 g2b

  14. Red pulp border Germinal Center T cell zone B cell zone

  15. SHM Occurs in the Germinal Center B Cells

  16. SHM Occurs in Germinal Center B Cells Primary focus

  17. Red pulp border plasmablasts Primary focus T cell zone T cell zone Germinal Center

  18. sIgM sIgM and sIgG

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