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Dr Motlalepula G. Matsabisa Indigenous Knowledge Systems [Health] Medical Research Council – South Africa Portfolio Committee on Health April 11 th 2004. Our Mission and Vision
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Dr Motlalepula G. Matsabisa Indigenous Knowledge Systems [Health] Medical Research Council – South Africa Portfolio Committee on Health April 11th 2004
Our Mission and Vision To promote and advance indigenous knowledge systems through research and development by making it a valued health model in the global environment and to redress health traditions, which until now have neglected health research priorities and issues. To be a centre of excellence in traditional medicines research regionally and to be competitive globally
Objectives • Coordination and development of health research in indigenous knowledge • Institutional and community networks • Development of an enabling clinical trial environment • Innovations and commercialization in traditional health systems. • Policies governing intellectual property and benefit-sharing • Research programmes that are appropriate & relevant • Support academic research • Funding
CEO Interim: Prof AD Mbewu Research Directorate IKS Lead Programme Director Dr MG Matsabisa IKS Research and Development IKS Utilization SBU IKS Knowledge Management Drug Discovery Clinical Trials Toxicity New Research Methodologies Poverty Eradication Programmes Pilot Farms Horticulture Production GMP Databases National Reference Centre Health Promotion Policy Advocacy Healer Liaison IKS Laboratory IKS ResourceCentre IKS Production Facility & Quality Control Laboratory DELFT: MRC’s Core IKS Facilities
Current Projects IKS Research and Development IKS Knowledge Management IKS Utilization (SBU) Research Policy Database Special Projects DELFT CENTRE MALARIA IK TRUST TRAMED III • Medicinal Garden Project • Training Programme ACCESS & BENEFIT-SHARING HYPERTENSION HIV AND AIDS School outreach program NHKN IKS RESEARCH GUIDELINES TUBERCULOSIS CLINICAL TRIALS PLATFORM TRADITIONAL HEALERS IP POLICY FARM CANCER MCC - ATMC TDr Program PAIN MONONGRAPHS NATIONAL REFERENCE CENTRE for ATM POVERTY ALLIVIATION DIABETES TRADITIONAL HEALTH CLAIMS TOXICOLOGY
Preclinical studies Clinical studies Malaria
C30H28O6 C30H28O7
Resistance Modulators Cancer Antibiotics Malaria HIV and AIDS
HIV and AIDS • Assessment of Traditional Claims for cures • Safety, Efficacy studies • Value addition
Clinical Trials Ethics Ethics:Informed consent for screening Informed consent for HIV testing Informed consent for participation in the study Information leaflet for the screening Information leaflet for participation in the study Counseling: Integrated approach: To whole family Pre-screening HIV counseling 1 post screening counseling (referral of those that are HIV+, but not meeting the inclusion criteria to appropriate & accredited centres for support) Ethical approval: (scientific and ethical merits) Protocols are peer-reviewed Submitted to MRC & MCC’s Clinical Trials Committee (CTC) for ethical evaluation Toxicology 90-day sub chronic study on a non-human primate model Clinical Human Trials Both Phase I and II/III Are double blind, randomized, placebo controlled dose elevation parallel group studies
Case Studies Extract A SO 86% Extract B PT 96% Extract C Cm & g 86%
HIV and AIDS • Training • School Outreach • Community Partnership • Medicinal Herb Garden
MRC Delft Community Project • Provide enabling environment for healers and scientists to interact • Formal structure for healers to interact, develop policy and develop communication products • Provide healers access to scientific infrastructure (Information, Library, Internet access, database, medicinal plant cultivation, drug discovery, Resource Centre) • Provide a forum for structured health education and promotion (Herb garden) • Develop skills in growing, processing, packaging and marketing of herbal products
School out-reach Program and TDr Training Program [photos not included]
IKS Utilization • Strategic Business Unit • Socio-economic Development • Poverty Elimination • Manufacturing
Organizational Structure DST Health Education Agriculture MRC Skills transfer Skills transfer Entrepreneurial skills development Community Commercial Partner Municipality Skills transfer Business development Infrastructure Land Markets Nursery Commercial farming
MethodologyTHE VALUE ADDED CHAIN Creation (Patents, Innovations) Knowledge Point of entry Existing IndustriesServices _________________________________________________ Industries Point of entry Emerging Industries Agriculture
Theoretical model MARKET Commercial viability (2) • INSTITITONAL • SUPPORT • (1) • MRC • Municipalities • Private sector • INDUSTRY • (5) • Partnerships Technical viability (3) Entrepreneurial viability (4)
Kimberley Municipality: Senqu Place: Sterkspruit Municipality: Tsolwana Place: Hofmeyer/ Tarkastad
Anticipated Impact Job creation Sustainable use of medicinal plants Application of scientific research developed by the IKS Lead Programme Capacity building for institutions (municipalities) Training and promotion of the culture of entrepreneurship The promotion of registered business ventures fully owned by emerging entrepreneurs Horizontal and vertical integration of the area surrounding the projects.
Systems – Mechanisms of Action Analytical analysis Quality Control Manufacturing Proteomics Genomics Metabolimics Cytochrome P540 1a2 2a 2c19 2d6 2c8 2c9 2e1 3a4 IKS Technologies
How to Contact Us Indigenous Knowledge Systems [Health] Lead Programme Dr MG Matsabisa – Director Tel. +27 21 938 0475 Fax. +27 21 938 0410 E-mail. Motlalepula.matsabisa@mrc.ac.za Website: www.mrc.ac.za “Going back to our roots for innovative health solutions”