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Understanding the Two-Component Signaling Paradigm

Learn about the 2CS signaling paradigm involving sensor proteins, response regulators, and phosphorelay reactions. Explore autophosphorylation, phosphotransferase, and phosphatase reactions in the system reset. Discover examples like osmoregulation transduction.

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Understanding the Two-Component Signaling Paradigm

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  1. 2 Component Signaling 20.20(S11) N Kuldell

  2. As simple as the box it comes in…

  3. The 2CS paradigm: in general Sensor protein Response regulator

  4. The 2CS paradigm: Phosphorelay rxns Slide from Mike Laub

  5. The 2CS paradigm: Phosphorelay rxns Sensor Sensor Sensor Sensor P Responder (inactive) P Responder RXN 1: Autophosphorylation in response to stimuli RXN 2: Phosphotransferase from Sensor to Response regulator RXN 3: Phosphatase inactivates Response regulator, resets system

  6. 2CS examples: Osmoregulation 2CS transduction, Hoch and Silhavy

  7. As simple as the box it comes in… Color Generating Device Light Sensing Device

  8. As simple as the box it comes in… Color Generating Device Light Sensing Device

  9. the end

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