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Understanding DNA Helix: Reading and Recognition Process

Review undergraduate-level Biochemistry lectures on DNA helix reading by exploring chemical interactions and major/minor grooves. Prepare for advanced material in graduate studies.

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Understanding DNA Helix: Reading and Recognition Process

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  1. G3 course reading - Tantin MBIOL 6420 8:30-9:30 ASB 210 Dean Tantin, PhD X7-3035, dean.tantin@path.utah.edu Required course reading For many of you, this is a review of undergraduate material. Some of this is a review of Biochemistry lectures you just had. But study (not read) slides in advance of the first day of my lectures. There is much that is testable in here. You are graduate students now: things in the next few lectures will rely on you already knowing this material.

  2. The DNA helix and how it is read 22Å 12Å 34Å 22Å Yellow: zinc finger protein recognizing DNA. Spheres: zinc ions each holding a zinc finger motif together

  3. The DNA helix and how it is read Chemical groups (mostly hydrogen bond donors and acceptors) exposed in the major and minor grooves provide information about sequence. More on this Monday. The sequence is“read” through specific chemical interactions (e.g., hydrogen bonding) with AA side chains of transcription factors that can only recognize the chemical groups in a specific pattern.

  4. The DNA helix and how it is read Major groove Major groove + - Minor groove Minor groove

  5. The DNA helix and how it is read AT/TA and CG/GC cannot be discriminated in the minor groove C. Correll and P. Rice, 2008

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