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Sydnone Chemistry and Microwave Assisted Synthesis of Sydnonyl-Substituted Imidazoles (I)

Sydnone Chemistry and Microwave Assisted Synthesis of Sydnonyl-Substituted Imidazoles (I). Mei-Hsiu Shih Department of Chemical and Material Engineerin g Southern Taiwan University of Technology. Outline. (Ⅰ) Introduction of sydnone chemistry (Ⅱ) Sydnonyl-substituted pyrazolines

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Sydnone Chemistry and Microwave Assisted Synthesis of Sydnonyl-Substituted Imidazoles (I)

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  1. Sydnone Chemistry and Microwave Assisted Synthesis of Sydnonyl-Substituted Imidazoles (I) Mei-Hsiu Shih Department of Chemical and Material Engineering Southern Taiwan University of Technology

  2. Outline (Ⅰ) Introduction of sydnone chemistry (Ⅱ) Sydnonyl-substituted pyrazolines (Ⅲ) Thiadiazoline and thiadiazole derivatives (Ⅳ) Microwave assisted synthesis of sydnonyl- substituted imidazoles

  3. (Ⅰ) Introduction of sydnones (A) Background Sydnone was first discovered by Earl and Mackney in 1935. They obtained a five-membered cyclic compound by the action of acetic anhydride on N-nitro-N-phenylglycine. Electronic structure and varied types of biological activity.

  4. (B) General synthetic procedure Sydnones were generally prepared by the action of certain dehydrating agents, notably acetic anhydride, on the N-nitroso derivatives of N-substituted α–amino acids.

  5. (C) Physical and chemical properities (D) Biological activity (E) Syntheses of 4-heterocyclic substituted sydnones Tetrahedron, 2002, December, 58, 10437-10445. Tetrahedron, 2003, June, 59, 4103-4111. Bioorganic & Medicinal Chemistry, 2004, September, 12, 4633-4643 Synthesis, 2004, December, 17, 2877-2885.

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