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NIH …

NIH …. vermam@mail.nih.gov. Turning Discovery Into Health. NATIONAL INSTITUTES OF HEALTH ( nih ) RESEARCH RESOURCES IN BIOTECHNOLOGY. Mukesh Verma, Ph.D. Chief Methods and Technologies Branch Program Director, Epidemiology and Genomics Research Program

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NIH …

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  1. NIH… vermam@mail.nih.gov Turning Discovery Into Health

  2. NATIONAL INSTITUTES OF HEALTH (nih) RESEARCH RESOURCES IN BIOTECHNOLOGY Mukesh Verma, Ph.D. Chief Methods and Technologies Branch Program Director, Epidemiology and Genomics Research Program Division of Cancer Control and Population Sciences National Cancer Institute (NCI) National Institutes of Health (NIH)

  3. Outline • NIH: Mission and Organization • Different Institutes • National Cancer Institute: an Example • Cancer Prevention and Other Research Priorities at the NCI • Grants: Review Process • Guidelines for Students: Who Would Apply for Funding • RePORT, eRA Commons • Solicited and Unsolicited Grant Applications • Job Opportunities, Fellowships at NIH

  4. National Institutes of Health www.nih.gov • NIH is the nation's medical research agency – making important medical discoveries that improve health and save lives. • The National Institutes of Health (NIH), a part of the U.S. Department of Health and Human Services, is the primary Federal agency for conducting and supporting medical research.

  5. www.nih.gov

  6. National Cancer Institute

  7. Search Engine

  8. NIH Budget The NIH invests over $30 billion annually in medical research for the American people. More than 80% of the NIH’s funding is awarded through almost 50,000 competitive grants to more than 212,000 researchers at over 2,800 universities, medical schools, and other research institutions in every state and around the world. About 10% of the NIH’s budget supports projects conducted by nearly 6,000 scientists in its own laboratories, most of which are on the NIH campus in Bethesda, Maryland.

  9. The NCI Budget Emphasizes Extramural Research NCI Budget > $4B per year

  10. Budget of DCCPS • 854 DCCPS grants, totaling over $350M • 239 competing awards funded in FY 2008 • New R01s = 108 • New R21s = 48 • New R03s = 53 • All other competing awards = 30

  11. Breakdown of Budget

  12. Funding research • NIH supports external research in 3 ways: • Grant:Investigator decides the research design and approach • Contract:Government decides the research scope to fill need and establishes detailed requirements • Cooperative Agreement:Similar to grant, BUT both awarding Institute/Center and recipient have substantial involvement in design and conduct of the research

  13. Different Types of Grants • Small Grants (R03) • Exploratory Grants (R21) • Investigator Initiated Grants (R01) • Program Project Grants (P01) • Cooperative Agreements (U01) • SBIR/STTR (R41/R42/R43/R44) Multiple PI Mechanism is Applicable in All Grants.gov Cancer.gov

  14. Other Types of Mechanisms DP1 NIH Director’s Pioneer Award (NDPA)DP2 NIH Director’s New Innovator AwardsDP3 Type 1 Diabetes Targeted Research AwardDP4 NIH Director’s Pathfinder Award- Multi-Yr FundingDP5/UP5 Early Independence Award/Cooperative Agreement P01/PL1 Program Project Grant/Linked Program ProjectP20 Exploratory GrantsP30 Center Core GrantsP40 Animal (Mammalian and Nonmammalian) Model, and Animal and Biological Material Resource GrantsP41 Biotechnology Resource GrantsP50 Specialized Center

  15. Grant Review Process CSR Major Steps 1-3 Months Submission and assignment 4-6 Months Review and Summary Statement 7-9 Months Human Sub etc and Award Video of the Review Process: http://cms.csr.nih.gov/ResourcesforApplicants/InsidetheNIHGrantReviewProcessVideo.htm

  16. Overall Timeframe from Submission to Award • There are three overlapping cycles per year : JAN FEB MAR APR MAY JUN JUL AUG SEP OCT NOV DEC JAN FEB MAR APR MAY JUN JUL Cycle1 Receipt Review Council Award Referral Cycle 2 Receipt Council Review Award Referral Cycle 3 Receipt Council Review Award Referral

  17. Training and Fellowship Grants (T and F Series)

  18. Cancer Training Grants—K Awards • Career Development Awards • K07: Cancer Prevention, Control, Behavioral, and Population Sciences Career Development Award • K22: NCI Transition Career Development Award • K23: Mentored Patient-Oriented Research Career Development Award • K24: Mid-Career Investigator Award in Patient-Oriented Research • K99/R00: NIH Pathway to Independence Award

  19. https://commons.era.nih.gov/commons

  20. Registered Organizations

  21. Pancreatic Cancer

  22. DIRECTORY NIH https://ned.nih.gov/search/search.aspx

  23. Jobs at NIH http://www.jobs.nih.gov/

  24. Research Training

  25. Summer Training Student Postdoctoral http://www.training.nih.gov/

  26. NCI Strategic PrioritiesSetting Course for Accelerated Progress • Molecular Epidemiology: Understanding Causes of Cancer • Early Detection, Prevention, Prediction • Integrative Cancer Biology • Strategic Development of Cancer Interventions • Integrated Clinical Trials System • Overcoming Health Disparities • Bioinformatics

  27. Tobacco Control • Diet • Physical Activity • Sun Exposure • Virus Exposure • Alcohol Use • Chemoprevention Focus • Communications • Surveillance • Social Determinants and Health Disparities • Genetic Testing • Decision Making • Evidence Based Healthcare • Quality of Cancer Care • Epidemiology Cross Cutting Issues THE CANCER CONTROL CONTINUUM Prevention Detection Diagnosis Treatment Survivorship • Informed Decision Making • Clinical Follow-up • Imaging • Pap Test • Mammography • FOBT • Endoscopy • PSA Informed Decision Making • Health Services and Outcomes Research • Clinical Trials • Palliation • Coping • Health Promotion

  28. http://www3.cancer.gov/prevention/

  29. http://camp.nci.nih.gov/dccps/

  30. Epidemiology and Genetics Research Program (EGRP) EGRP manages a comprehensive program of grant-supported, population-based research that brings to bear the expertise of scientists to increase our understanding of cancer etiology and prevention. Scientists from throughout the United States and internationally are supported. Epigenetic Factors EGRP

  31. MRFB and CTEB Modifiable Risk Factors Branch Supports research into factors that may be modifiable, such as diet and nutrition, alcohol, physical activity and energy balance, tobacco, infectious diseases, physical and chemical agents, and medical exposures. Clinical and Translational Epidemiology Branch Supports research into clinical factors that influence development of cancer among persons with underlying diseases and conditions; the progression, recurrence, and mortality from cancer; and new primary cancers.

  32. HSFB and MTB Host Susceptibility Factors Branch Supports research on personal susceptibility factors such as genetic, epigenetic, immunological and hormonal biological pathways, and social, cultural and race/ethnic factors. Methods and Technologies Branch Supports research into methods addressing epidemiologic data collection, study design and analysis, and to modify technological approaches developed in the context of other research endeavors for use as biomarkers and methods to understand cancer susceptibility.

  33. Special Populations in EGRP African-American men & women South American women Asian-American & Asian men & women Latin-American/Hispanics African men & women Alaskan & Hawaiian Natives Middle-Eastern populations American-Indian, incl. Navajo Rural South

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