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Structure du génome

Pas de coiffe. Intervient dans la synthèse du brin Ө. Intervient dans la régulation de la traduction, la virulence et l’encapsidation. Vpg (24 aam) liaison phosphodiester TRY-pUp, viral protein genome linked. Structure du génome. 740 = AUG. 15 à 90 A = poly A. 7361. 7433. 5’. 3’.

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Structure du génome

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  1. Pas de coiffe Intervient dans la synthèse du brin Ө Intervient dans la régulation de la traduction, la virulence et l’encapsidation Vpg (24 aam) liaison phosphodiester TRY-pUp, viral protein genome linked Structure du génome 740 = AUG 15 à 90 A = poly A 7361 7433 5’ 3’ Protéines Protéines structurales non structurales

  2. 3’ 5’ Traduction COOH Polyprotéine (NCVP) H2N Clivages protéolytiques P1 P2 P3 La protéase est active dès sa synthèse dans la NCVP VP3 VP1 VPg VP0 VP2 { VP4 Réplicase Protéines de capside du virion Protéase Organisation du génome du Poliovirus(type ARNm, monocistronique)

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