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Coccidiosis Poultry Vaccines. Akzo Nobel N.V. (Intervet) British Technology Group U.S.A., Inc. USDA Enzon Hoffmann-La Roche Solvay & Cie, S.A. Pfizer. Coccidiosis Poultry Vaccines. Akzo Nobel N.V. (Intervet) British Technology Group U.S.A., Inc. USDA Enzon Hoffmann-La Roche
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Coccidiosis Poultry Vaccines • Akzo Nobel N.V. (Intervet) • British Technology Group U.S.A., Inc. • USDA • Enzon • Hoffmann-La Roche • Solvay & Cie, S.A. • Pfizer
Coccidiosis Poultry Vaccines • Akzo Nobel N.V. (Intervet) • British Technology Group U.S.A., Inc. • USDA • Enzon • Hoffmann-La Roche • Solvay & Cie, S.A. • Pfizer
Eimeria in Poultry • Eimeria tenella • Eimeria necatrix • Eimeria acervulina • Eimeria maxima • Eimeria brunetti • Eimeria mivati • Eimeria mitus • Eimeria meleagrimitis • Eimeria adenoides
Coccidiosis Poultry Vaccines • Akzo Nobel N.V. (Intervet) • British Technology Group U.S.A., Inc. • USDA • Enzon • Hoffmann-La Roche • Solvay & Cie, S.A. • Pfizer
Eimeria in Poultry • Eimeria tenella • Eimeria necatrix • Eimeria acervulina • Eimeria maxima • Eimeria brunetti • Eimeria mivati • Eimeria mitus • Eimeria meleagrimitis • Eimeria adenoides
Sporozoite proteins Merozoite proteins E. acervulina E. tenella 200 kD 100 kD 50 kD 20 kD US5843722 US5814320 US5795741 US5792644 US5789233 US5783197 US5780289 US5677438 US5670362 US5614195 US5602033 Eimeria vaccines Akzo Nobel N.V.
Economic Impact of coccidiosis • US 300 Mio $ loss/year • (3 billion broilers estimate (6.741 in 1997) • US 100 Mio to 150 Mio/year • NovoPlant 150 to 250 Mio $ USA • 15-30 Mio DM in BRD 1997 bei 750 Mio Produktion • 160-320 Mio DM in EU 1996 • 1.0 to 2.0 cents/ kg • 13 Mio Guilders in NL
Effectiveness of Vaccination against E. tenella 4 week old birds, 2.4 mg antigen, 75,000 oocysts, US Patent 5279960
Recombinant anticoccidial vaccine(US5635181 BTG) Challenge with 90000 oocysts of E.tenella, E.mitis, E.acervulina, E.maxima, E. brunetti * 10 6 oocysts / g feces
Protection against E. acervulina infection US5783197 Vermeulen et al.
MABs against sporozoite antigens can reduce rate of E.tenella infection
Methods of Vaccination against Eimeria • Fowl pox virus • Yeast surface protein • Bacterial surface protein • Injection • Drinking water • Feed US4710377 Schenkel et al.