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NCESR 06/07-101

Ethanol as a Energy Source and Terminal Reductant: Exploitation of Thermophilic Redox Enzymes in Catalyst Development and Screening Ketones. Co-PI’s:. David Berkowitz , Department of Chemistry. Paul Blum , School of Biological Sciences. NCESR 06/07-101.

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NCESR 06/07-101

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  1. Ethanol as a Energy Source and Terminal Reductant:Exploitation of Thermophilic Redox Enzymesin Catalyst Development and Screening Ketones Co-PI’s: David Berkowitz, Department of Chemistry Paul Blum, School of Biological Sciences NCESR 06/07-101

  2. New Value-Added Enzymatic Reductions of Achiral Ketones New Biocatalytic Routes to Pharmaceutically Relevant Building Blocks . . . HLADH = Horse Liver Alcohol Dehydrogenase; CPADH = Candida parapsilosis ADH; RS-1 ADH = Rhodococcus sp. ADH; LKADH = Lactobacillus kefir ADH

  3. Ethanol as the Terminal Reductant for Value-Added Products: 300-500 reduction cycles possible from ethanol in the synthesis of this value-added chiral, building block . . .

  4. Thermophilic Bacteria as a Potential Source of Novel Dehydrogenases:

  5. The Blum Lab successfully expresses the thermostable ADH from the archeaon Sulfolobus sulfataricus:

  6. The Berkowitz Lab finds that this thermostable ADH can enantioselectively reduce the Talampanel-leading ketone, even at 75°C

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