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Evidence for osteocyte regulation of bone homeostasis through RANKL expression

Evidence for osteocyte regulation of bone homeostasis through RANKL expression. Osteoscoop - Issue N°214 – December 2011. Osteoblast. RANK. Osteoclast. RANKL. ?. Cell differentiation. ?. Preosteoclast. RANKL. Osteocytes. Osteoblast. RANK. Osteoclast. RANKL. ?. Cell

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Evidence for osteocyte regulation of bone homeostasis through RANKL expression

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  1. Evidence for osteocyte regulation of bone homeostasis through RANKL expression Osteoscoop - Issue N°214 – December 2011

  2. Osteoblast RANK Osteoclast RANKL ? Cell differentiation ? Preosteoclast RANKL Osteocytes

  3. Osteoblast RANK Osteoclast RANKL ? Cell differentiation ? Preosteoclast RANKL Osteocytes WT mice cell fractionation - purification RANKL mRNA level >> 30 3 Osteoclasto-genesis High capacity lower capacity >>

  4. Osteoblast RANK Osteoclast RANKL ? Cell differentiation ? Pre-osteoclast RANKL Osteocytes Osteocyte specific Rankl D/D osteopetrotic mice cell fractionation - purification WT mice cell fractionation - purification RANKL mRNA level >> 0 WTlevel << 30 3 Very low capacity WT capacity Osteoclasto-genesis High capacity lower capacity << >>

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