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HIPNOTIK SEDATIF

HIPNOTIK SEDATIF. REYMON, S.Si ., Apt. PENDAHULUAN. Hipnotik sedatif  gol . Obat depresan SSP, kurang selektif , menyebabkan kantuk , hingga hilangnya kesadaran . Pada dosis terapi obat sedatif menekan aktivitas , menurunkan respons thdp rangsangan emosi dan menenangkan .

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HIPNOTIK SEDATIF

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  1. HIPNOTIK SEDATIF REYMON, S.Si., Apt

  2. PENDAHULUAN • Hipnotiksedatif gol. Obatdepresan SSP, kurangselektif, menyebabkankantuk, hinggahilangnyakesadaran. • Padadosisterapiobatsedatifmenekanaktivitas, menurunkanresponsthdprangsanganemosidanmenenangkan. • Obathipnotikmenyebabkankantukdanmempermudahtidur.

  3. Fungsiobathipnotik • Pelemasotot • Antiepilepsi • Antiansietas • Preanastesi • Antidepresan • insomnia

  4. Obat-obathipnotiksedatif • Gol. Benzodiazepin • Gol. Barbiturat • Gol. Antidepresantrisiklik • Obat-Obat Lain

  5. Golonganobathipnotiksedatif Gol. Benzodiazepin potensiasi GABA menyebabkankanalCl-terbukashg neuron sukartereksitasi. Cthobatbenzodiazepin : • Diazepam Sedatifdgndosis 5-10 mg, digunakansbgantidepresan, antiansietas • Alprazolam ansietas : 0,5-4 mg/haridlmdosisterbagi, 2,5-3 mg/haridlmdosisterbagi. sbgantidepresan, antiansietas

  6. Triazolam Hipnotik, 0,125-0,5 mg tdd Gol. Barbiturat • Fenobarbital • Pentobarbital • Sekobarbital • Natriumtiopental

  7. Gol. Antidepresantrisiklik • Amitriptilin • Amoxapin • Clomipramine • Despiramine • Doxepin • Imipramin • Nortriptilin • Protriptilin • Trimipramin

  8. Amitriptilin • Dosis : 25 mg • Interval : 8 jam • Waktuparuh : 24-40 jam • Ikatan protein : 96% • Vol. distribusi : 6-36 L/kg • Efeksamping :retensiurin, hipertensiortostatik.

  9. Amoxapin • Dosis : 75-200 mg • Interval : 24 jam • Waktuparuh : 8-30 jam  metabolitaktif • Ikatan protein : 90% • Vol. distribusi : - • Efeksamping :retensiurin, hipertensiortostatik.

  10. Imipramin • Dosis : 25 mg • Interval : 8 jam • Waktuparuh : 12-24 jam • Ikatan protein : 96% • Vol. distribusi : 10-20 L/kg • Efeksamping :retensiurin, hipertensiortostatik.

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