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Plant toxins John Carlo Macuja Jackielyn Ocbina III-BSCT

Plant toxins John Carlo Macuja Jackielyn Ocbina III-BSCT. Chemical and Molecular Toxicology. Western Water Hemlock. Kingdom-  Plantae Subkingdom-  Tracheobionta Superdivision- Spermatophyta Division-  Magnoliophyta Class-  Magnoliopsida Order- Apiales Family-  Apiaceae.

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Plant toxins John Carlo Macuja Jackielyn Ocbina III-BSCT

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  1. Plant toxinsJohn Carlo MacujaJackielynOcbinaIII-BSCT Chemical and MolecularToxicology

  2. Western Water Hemlock • Kingdom-  Plantae • Subkingdom-  Tracheobionta • Superdivision- Spermatophyta • Division-  Magnoliophyta • Class-  Magnoliopsida • Order- Apiales • Family-  Apiaceae

  3. Western Water Hemlock • Scientic Name: Cicuta douglasii • Western water hemlock is a poisonous plant in the family Apiaceae. It is a perennial plant that grows in wet places such as marshes, stream banks, slough margins, ditches, meadows, and wet pastures • It is the most poisonous plant in North America.

  4. Western Water Hemlock

  5. Western Water Hemlock • Toxin- cicutoxin • Cicutoxin is the poisonous substance found in water hemlock (Cicuta species). • It is a natural product structurally related to the oenanthotoxin of hemlock water dropwort.

  6. Western Water Hemlock • Cicutoxin is a yellowish liquid that is prevalent in the roots.

  7. Western Water Hemlock It is an unsaturated alcohol

  8. Western Water Hemlock • Oenanthotoxin is found in the plant hemlock water dropwort

  9. Western Water Hemlock Effects in the body • Its primary effect is the disruption of the central nervous system. • Cicutoxin acts as a non-competitive gamma-aminobutyric acid (GABA) receptor antagonist. • Cicutoxin acts on the GABAA receptor causing a block of the chloride channel which results in neuronal depolarization.

  10. Western Water Hemlock • GABAA receptor • In the presence of cicutoxin this depolarization continues unabated causing cell overactivity. The hyperactivity in brain cells results in seizures

  11. Western Water Hemlock Symptoms • Signs of poisoningcanoccurwithin 15 mins • This includenausea, vomiting, abdominal pain, muscle twitch, rapid pulse, rapid breathing, tremors, seizures, excessive salivation or frothing of the mouth, and dilation of pupils

  12. Western Water Hemlock • Symptoms • Deaths usually occur from respiratory failure or cardiac arrest • Treatment • Initial treatment of poisoning may include gastrointestinal decontamination with activated charcoal • There is no specific antidote for water hemlock poisoning and treatment mainly consists of supportive care

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