Hematopoietic Database and Manual

1. Hematopoietic Database and Manual Changes made in 2014

2. Starting in 2014, there will be only one Hematopoietic Database. It will cover all of the hematopoietic diseases diagnosed from Jan. 1, 2010 forward. • Although there were changes to the MP rules, SEER is NOT requiring a review of cases already coded.

3. Summary of Changes • All Hodgkin Lymphomas (9650-9667) had primary site C77._ added in the primary site column. Although rare, HD can occur in extranodal sites. [C77._ is the default site.] • Specific grades were added to many histologies (same as found in the 2010 Heme DB). • All Obsolete codes, marked as [OBS], are effective as obsolete as of Jan. 1, 2010. [Some were eff. in 2012.] • A majority of changes were the correction of typographical errors; others include the addition of alternate histology names or the [OBS] indicator. • There are some rule changes in the PH modules of the Manual.

4. Types of Changes • Changes to the Hematopoietic Database • Changes to what is considered SAME vs NEW primary • Changes to what are considered Transformations of certain histologies • Change in Reportability • Changes to the Hematopoietic Manual

5. Summary of changes in what is SAME vs NEW primary These changes may affect case counts (Incidence): • For all [OBS] codes, the new (‘referred to’) code should always be the SAME primary. This was not always the case, and has been corrected in the 2014 database. • Therapy-related myeloid leukemia (9920) and Therapy-related MDS [OBS] (9987, see code 9920) should have no SAME primaries other than each other. • Chronic myeloproliferative disease, NOS [OBS] (9960) was found to have errors in the SAME primary list and in the transformations. These have been corrected; 9960 now has the SAME primaries and transformations as 9975 (Myelodysplastic / myeloproliferative neoplasm, unclassifiable).

6. Summary of changes in what isSAME vs NEW primary • Myelodysplastic diseases (9980–9986, 9991-9992) should always be the SAME primary. • Follicular lymphomas (9690, 9691, 9695, 9698) are always the SAME primary. • For some histologies, additional SAME primaries were added which were left out of the 2010 release.

7. Table of SAME Primary: additions and deletions (see handout for full Table)

8. Number of cases affected in KY by these changes • Review of all Therapy related AML and Therapy related MDS cases to see if a second primary might exist would mean review of 2759 cases in KY. • Review of all Chronic Myeloproliferative Disease cases (9960) would entail review of 613 cases in KY. • Review of all cases where two primaries should be only one involves 48 cases. KCR will ask you to review these situations.

9. Changes in Transformations • The “Transformations” field has been relabeled “Transformations to.” If a chronic neoplasm can transform to an acute/more severe neoplasm, the Heme DB will show the acute neoplasm in the “Transformations to” section. • A new field has been added to the database: “Transformations from.” This field was added to help registrars determine which histologies are chronic and which are acute. • Acute neoplasms have other histologies listed in the “Transformations from” field. • Chronic neoplasms ARE thehistologies listed in the “Transformations from” field.

10. Changes in list of Transformations • For some histologies, there were changes in the list of histologies considered ‘Transformations to’. • For example, the histologies that had 9861/3 (Acute Myeloid Leukemia, NOS) listed as a transformation, the additional AML histologies were also added as transformations: 9865/3, 9866/3, 9867/3, 9869/3, 9871/3, 9872/3, 9873/3, 9874/3, 9895/3, 9896/3, 9897/3, 9911/3.

11. Table of changes to Transformations (see handout for full Table)

12. Changes in list of Transformations • Transformations may be new primaries depending on the application of MP Rules 10-15. For example, 9700 (Mycosis Fungoides) used to have a lot of histologies listed as Transformations. • Further review of 2008 WHO Hematopoietic book confirmed that Mycosis Fungoides (9700/3) has no transformations. Review of the histologies that had been listed as transformations but are now deleted could identify cases where Mycosis Fungoides was also present. If MF was present, this would automatically be a second primary per Rule M17 (previously M16).

13. Changes in Transformations • Review of all cases involved with changes to their malignant transformations list would entail review of 7033 cases in KY.

14. Change in Reportability • Plasma Cell Neoplasm: This was not listed in the 2010 manual but was added in the 2012 manual and is to be removed for 2014. • Plasma cell neoplasm is an umbrella term for various diseases, some reportable others not reportable. • If collected, morpholology would have been coded as 9731/4 or 9734/3. If reviewing these records, see if they were abstracted based on the term “plasma cell neoplasm.” If further studies or workup diagnosed a reportable diagnosis, then that case is maintained in the database; otherwise it should be deleted.

15. Changes in Reportability • Review of all cases abstracted as 9731 or 9734 would entail review of 99 cases in KY.

16. Changes to the Hematopoietic Manual The 2014 revisions include: • • Rule clarification and revision • • Correction of typos (in both manual and database) • • Simplification of rules and reference to database

17. DEMO of on line Hematopoietic Database