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Are Combinations the Solution: Perspectives on Combination Immunotherapy

Are Combinations the Solution: Perspectives on Combination Immunotherapy.

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Are Combinations the Solution: Perspectives on Combination Immunotherapy

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  1. Are Combinations the Solution: Perspectives on Combination Immunotherapy

  2. This program will include a discussion of off-label treatment and investigational agents not approved by the FDA for use in the United States, and data that were presented in abstract form. These data should be considered preliminary until published in a peer-reviewed journal.

  3. Immunotherapy: Paradigm on the Rise

  4. MOA of Inhibitors on PD-1 Pathway

  5. FDA Approved PD-1/PD-L1 Inhibitors

  6. Toxicity With PD-1/PD-L1 Inhibitors

  7. Predictive Biomarkers Are Lacking

  8. PD-1 and CTLA-4 Inhibition in Melanoma

  9. CheckMate 069

  10. What About Other Tumors?

  11. CheckMate 012

  12. Durvalumab/Tremelimumab in NSCLC

  13. Toxicity in a Broader Population

  14. Immunotherapy Is Not Chemotherapy

  15. Immunotherapy/Immunotherapy Summary

  16. Chemoimmunotherapy

  17. KEYNOTE 021

  18. KEYNOTE 024

  19. Chemotherapy/Immunotherapy Summary

  20. Overcoming Challenges of Targeted Therapies

  21. PD-1/BRAF/MEK Inhibition in Melanoma

  22. PD-1/EGFR Inhibition in NSCLC

  23. TATTON Results: EGFR/PD-L1 Inhibition

  24. Is Immunotherapy the Right Approach?

  25. Mutational Load in Never Smokers

  26. Targeted Therapy/Immunotherapy Summary

  27. Overall Conclusions

  28. Abbreviations

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