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Nutrigenomics. KNH 413. Nutrigenomics and Disease. Cancer Use of omega-3 & EPA for rare types Predicting benefit difficult in other types Responders and non-responders Colon cancer Folate intake and alcohol Fruits and vegetables Breast cancer Antioxidants. Nutrigenomics and Disease.
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Nutrigenomics KNH 413
Nutrigenomics and Disease • Cancer • Use of omega-3 & EPA for rare types • Predicting benefit difficult in other types • Responders and non-responders • Colon cancer • Folate intake and alcohol • Fruits and vegetables • Breast cancer • Antioxidants
Nutrigenomics and Disease • Obesity • Susceptibility with conducive environment • Polygenic trait • Promising research • Perilipin • Serotonin receptor gene promoter
Nutrigenomics and Disease • Thrifty Gene hypothesis • Metabolic status and fetal adaptation predict disease in adulthood • Proneness to metabolic syndrome, obesity, diabetes, CVD
Nutrigenomics and Disease • Diabetes • Focus on type 2 • Metabolic syndrome, insulin resistance • GLUT 2 • PPARy • APOE
Nutrigenomics and Disease • Cardiovascular Disease • Dyslipidemias • Familial hypercholesterolemia • PUFAs on HDL • Omega-3s and TG • Omega-6s and inflammation
Dietetics and Genetics • Understanding nutrient interactions and genes • Future of diet counseling • Beware of home testing kits • “DNA diet” • Sciona • Costly • EGAPP Project • To establish a coordinated process • Evaluation of genomic applications and practice/preventionq