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Diagnosis of Multiple Myeloma

Diagnosis of Multiple Myeloma. Choice of Initial Therapy. More toxic Less convenient. Is there a long-term benefit to more intensive up-front therapy?. Summary: Initial therapy. Summary: Transplant and maintenance. Bone therapy: outstanding questions. Imids thalidomide lenalidomide

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Diagnosis of Multiple Myeloma

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  1. Diagnosis of Multiple Myeloma

  2. Choice of Initial Therapy More toxic Less convenient Is there a long-term benefit to more intensive up-front therapy?

  3. Summary: Initial therapy

  4. Summary: Transplant and maintenance

  5. Bone therapy: outstanding questions

  6. Imids thalidomide lenalidomide pomalidomide PIs bortezomib carfilzomib ixazomib Steroids Dexamethasone Prednisone Cytotoxics cyclophosphamide melphalan doxorubicin bendamustine HDACi panobinostat MoAbs elotuzumab daratumumab

  7. Trials at Penn for first-line therapy

  8. Choosing triplets for relapsed myeloma

  9. Summary

  10. BiTE (bispecific T cell engager) Blinatumumab FDA-approved Baeuerle, Cancer Res 2009

  11. Immunotherapy targets for myeloma

  12. Cellular therapy in MM: what’s happening in 2019

  13. Comparison of immunotherapy approaches

  14. Conclusions and challenges

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