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Where to Find the Course: Home Page: gspp.berkeley/iths/RDStrategies/Home.htm Wiki:

Where to Find the Course: Home Page: http://gspp.berkeley.edu/iths/RDStrategies/Home.htm Wiki: https://bspace.berkeley.edu/portal. Designing Strategies for Neglected Disease Research Law 284.26 Public Policy 190/290. Course Overview: Thinking Through the Problem. Stephen M. Maurer.

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Where to Find the Course: Home Page: gspp.berkeley/iths/RDStrategies/Home.htm Wiki:

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  1. Where to Find the Course: Home Page: http://gspp.berkeley.edu/iths/RDStrategies/Home.htm Wiki: https://bspace.berkeley.edu/portal

  2. Designing Strategies for Neglected Disease Research Law 284.26 Public Policy 190/290 Course Overview: Thinking Through the Problem Stephen M. Maurer

  3. Where to Find the Course: Home Page: http://gspp.berkeley.edu/iths/RDStrategies/Home.htm Wiki: https://bspace.berkeley.edu/portal

  4. Owner’s Manual

  5. Owner’s Manual “The power of instruction is seldom of much efficacy except in those happy dispositions where it is almost superfluous." - Edward Gibbon

  6. Goals This is nominally … A Course About a Specific Innovation Problem (Mostly Economics) But you should think of it as … A Course About R&D Incentives Ongoing Research A Course About Giving Practical Advice (A Potential Initiative) The Hard (Also Rewarding, Interesting) Part…

  7. Interdisciplinary Problems

  8. Three views - Cartoon intuition - “How to do public policy” - A worked example.

  9. Interdisciplinary Problems Drugs for U.S. The Problem Drugs for Developing World

  10. Interdisciplinary Problems Drugs for U.S. Political Science – Redistribution Drugs for Developing World

  11. Interdisciplinary Problems Drugs for U.S. Biology & Engineering Drugs for Developing World

  12. Interdisciplinary Problems Drugs for U.S. This Course (Primarily) Drugs for Developing World

  13. Interdisciplinary Problems Drugs for U.S. Incentives Design Drugs for Developing World

  14. Interdisciplinary Problems 2 Doing Public Policy - Define Goals  Understand  Identify Bottlenecks Design a (Hopefully) Elegant Response.

  15. Interdisciplinary Problems 2 • Doing Public Policy • - Define Goals Understand  • Identify Bottlenecks Design a • (Hopefully) Elegant Response. • Define Goals • Choose an Objective Function!

  16. Interdisciplinary Problems 2 Doing Public Policy - Define Goals Understand Identify Bottlenecks Design a (Hopefully) Elegant Response. 2. Understand Take Theory Seriously - “Pharma doesn’t want to prevent diseases, selling drugs is more lucrative.” - “Prizes are only paid if you get a drug.” *Making Contact Between Theory and Evidence

  17. Interdisciplinary Problems 2 Doing Public Policy - Define Goals  Understand  Identify Bottlenecks  Design a (Hopefully) Elegant Response. 3. Identify Bottlenecks - What are the Main Innovation Challenges? - The Innovation Toolbox

  18. Interdisciplinary Problems 2 Doing Public Policy - Define Goals Understand Identify Bottlenecks Design a (Hopefully) Elegant Response. 4. Design a Response - “No dominant incentive mechanism” - What are the Main Innovation Challenges? - The Innovation Toolbox

  19. A Concrete Example: Prizes vs. PPPs Prizes How Big Should the Prize Be? $800m ± $115m PPPs Picking Winners Managing Outsourced R&D Getting the Best Ideas … And Also Patents? Access Pricing

  20. Recurring Themes Innovation Economics Efficient Procurement (Getting a Good Price) Usually: Efficiency: How intense do we want R&D effort to be? Here: Limited Budget: How much will it cost? Information Asymmetry/Agency Problems (Managing Outsourced R&D) Managers Don’t Know Everything Researchers May Have Diverging Goals

  21. Recurring Themes Innovation Economics, ctd… Eliciting Information (Getting Good Ideas) Good Ideas are (Often) Widely Distributed Counterexamples A prizes for reduced DALYs? A prize for optimized drug compounds? Efficient Access Patents Prices matter!

  22. Comment “It’s a Great Idea, But Government Will Never Listen” A Lawyer’s Faith

  23. Roadmap

  24. Roadmap Lecture Topic Speaker Week 1 Introduction AK, SM Jan. 13-15 Defining The Goals: Week 2 Disease Burdens Kirk Smith, Julia Jan. 20-22 R&D Priorities Walsh Week 3A The Drug Discovery David Ridley Jan. 27 Business Week 3B, Drug Development Jim McKerrow 4A Science; The Neglected Solomon Nwaka Jan. 29- Disease Pipeline

  25. Roadmap Lecture Topic Speaker Week Innovation Economics SM, AK 4B – 5B Feb. 5-12 Leading Proposals: Week 6A Price Discrimination and Keith Maskus Feb. 17 Patent Pools Week 6B Financing Proposals Saul Walker Feb. 19 Week 7A Prizes Aidan Hollis

  26. Roadmap Lecture Topic Speaker Week 7B Funding Clinical Trials Dean Baker Feb. 26 Week 8A Advanced Market Michael Kremer Mar. 3 Commitments Mar. 6 Critical Evaluations Due Week 9A Private Public Suerie Moon Mar. 10 Partnerships Week 9B Regulatory Approval David Kessler

  27. Roadmap Lecture Topic Speaker Week 10B Political Economy Richard Wilder Mar. 17-19 James Love Week 11-12 Incentive Design Choices SM, Brian Wright, Mar. 31- Economists Roundtable Suzanne Scotchmer Apr. 9 Week 13 Delivering Healthcare Julia Walsh Apr. 14-16 Ndola Prata Week 14 Student Papers; -- Apr. 20-21 Concluding Remarks

  28. Course Requirements

  29. Class Participation (25%) Wiki (In Class Discussion) Lecture Reporter

  30. Midterm Project Critique an Existing Initiative (25%) Self-assemble

  31. Final Project White Paper (50%) Groups of 4-6 students Ideal: Self-assemble!

  32. Logistics Home Page: http://gspp.berkeley.edu/iths/RDStrategies/Home.htm Wiki: https://bspace.berkeley.edu/portal

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