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TNIN Tecnologie Non Invasive per le Neuroscienze : Risonanza Magnetica

TNIN Tecnologie Non Invasive per le Neuroscienze : Risonanza Magnetica. Federico Giove federico.giove@roma1.infn.it. Mission. To develop and exploit NMR approaches for the neurosciences Visual system , Neuroenergetics BOLD, MRS, multimodal approaches , neurocurrents

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TNIN Tecnologie Non Invasive per le Neuroscienze : Risonanza Magnetica

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  1. TNINTecnologie Non Invasive per le Neuroscienze:RisonanzaMagnetica Federico Giove federico.giove@roma1.infn.it

  2. Mission • To develop and exploit NMR approaches for the neurosciences • Visual system, Neuroenergetics • BOLD, MRS, multimodalapproaches, neurocurrents • Structural (pathologies)

  3. BOLD

  4. … OR NEURONAL CURRENTS?

  5. FUNCTIONAL CONNECTIVITY MD Fox et al., PNAS 102:9673 (2005)

  6. FUNCTIONAL CONNECTIVITY

  7. PCC Hippocampus HS HS MCI AD MCI AD HS MCI AD From PPC seed-region L -Hippocampus GM atrophy Functional connectivity

  8. NK Logothetis, Nature 453:869 (2008)

  9. ASSESSING THE NEUROMETABOLIC COUPLING • To complement BOLD findings • 1H MRS drawbacks • Limited temporal resolution • Low spatial resolution • CREATE STATIONARY “DISENTAGLED” CONDITIONS • Add other modalities

  10. VISUAL PERCEPTION V1 responds to invisiblestimuli Activation of V1 per se isinsufficient for awareness Viswanathan and Freeman, Nat Neurosci 10:1308 (2007)

  11. fMRI RESULTS

  12. MRS RESULTS

  13. MRS RESULTS

  14. Marco Carnì Antonino M. Cassarà Mauro Di Nuzzo Michela Fratini Girolamo Garreffa, Marta Moraschi and Bruno Maraviglia (Fermi Center) Silvia Mangia (U Minnesota) TommasoGili (U Cardiff) Silvia Capuani, Giulia Di Pietro, Marco Palombo (U Sapienza)

  15. EXTERNAL COLLABORATORS NEUROPHYSIOLOGY, NEUROSCIENCES: NK Logothetis, GE Hagberg, Y Murayama (MPI Tuebingen), EmilianoMacaluso (Santa Lucia IRCCS) , Richard G Wise, Silvia De Santis (U Cardiff) CLINICAL RESEARCH M Bozzali, G Spalletta (Santa Lucia IRCCS) MODELLING: S Vannucci (Columbia), I Simpson (U Penn) , A Carruthers (U Massachusetts),A De Martino, E Marinari (U Sapienza) PAST COLLABORATORS M Bianciardi, S Peca, G Giulietti, M Rebuzzi, P Porcari, F Di Salle

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