How to maintain joint function.

1. How to maintain joint function. R.T. Clement, MD Richard Clement Nutrition. richardclementmd@yahoo.com www.web-outpatients.com

2. CAM • Complementary and Alternative Medicine use increased from 25% to 1990 to 42% in 1997 • Total visits to CAM providers in 1997 (629 million) exceeded total visits to all primary care physicians (386 million).

3. Arthritis • In the United States, about one out of every six people (nearly 43 million) is affected by arthritis

4. Medical Therapy • COX- 2 selective nonsteroidal anti-inflammatory drugs (NSAIDs) such as celecoxib and rofecoxib are now to be considered first-line drugs of choice for treating moderate to severe pain, and mild pain associated with inflammation.

5. COX-2 • The cardiovascular effects of COX-2 inhibitors were evaluated in a review of multiple studies published in the August 22 edition of the JAMA This review focused on two major studies in particular, each with over 8,000 participants: the Vioxx Gastrointestinal Outcomes Research Study (VIGOR) and the Celecoxib Long-term Arthritis Safety Study (CLASS).

6. COX-2 • VIGOR showed that Vioxx increased the risk of cardiovascular events, such as heart attack or stroke, almost two-and-a-half times. Two other smaller studies also suggested a relationship between Vioxx and these conditions. CLASS indicated an increased risk for cardiovascular events in COX-2 users, but was inconclusive because of minimal data.

7. Nutritional Supplements • 1 CHONDROITIN reduces inflammation. This effect is explained by many action mechanisms. First, it causes a decline in pro-inflammation prostaglandins. Then, it inhibits many enzymes secreted by chondrocytes including elastase and hyaluronidase. These enzymes are responsible for the elimination of old cartilage, making room for the new one.

8. Nutritional Supplements • 2 GLUCOSAMINE SULFATE is a supplement used in osteoarthritis. When orally given, it is more effective than placebo and at least as effective as non-steroidal anti-inflammatory drugs in relieving osteoarthritis symptoms..

9. Nutritional Supplements • 3 MSM is a Sulfur compound. The proper acid/alkaline balance of the body cannot be maintained without it. MSM can lower pain levels by 50% or more. MSM reduces inflammation and helps to restore mobility.

10. Nutritional Supplements • 4 CHICKEN COLLAGEN TYPE II Several controlled trials provide evidence that oral administration of type II collagen is both safe and can improve the clinical manifestations of active rheumatoid arthritis. The Harvard Medical School study found that several of the joint sufferers taking daily Type II Collagen from chicken cartilage were able to successfully decrease or, in some cases, eliminate joint medication

11. Nutritional Supplements • 5 FLAXSEED is derived from the flax plant.. Flaxseed is rich in alpha-linolenic acid (ALA), an essential fatty acid that appears to be beneficial for heart disease, inflammatory bowel disease, arthritis, and a variety of other health problems.. Several studies suggest that omega-3 fatty acids help reduce tenderness in joints, decrease morning stiffness, improve mobility, and allow for a reduction in the amount of medication needed for people with rheumatoid arthritis and, probably, osteoarthritis as well.

12. Nutritional Supplements • 6 BROMELAIN is a general name for a family of sulfhydryl-containing, proteolytic enzymes obtained from Ananas comosus, the pineapple plant. • Bromelain’s primary component is a sulfhydryl proteolytic fraction. Bromelain also contains a peroxidase, acid phosphatase, several protease inhibitors, and organically bound calcium.

13. Nutritional Supplements • 7 BOSWELIA (active ingredient - terpenoids). Boswelia has been used to treat osteoarthritis. Boswelia behaves much like other NSAID’s (i.e., aspirin, Motrin, Celebrex) in that it decreases inflammation. It does so by decreasing the number of leukotrienes, one of the molecules responsible for causing inflammation.

14. Nutritional Supplements • 8 CURCUMIN Turmeric (Curcuma Longa)Turmeric is a spice from Asia, in the ginger family. It is mainly used in curries and as a yellow coloring agent in food. Its anti-inflammatory property in osteoarthritis may be due to its effect on the eïcosanoïd biosynthesis and the arachidonic acid pathway enzymes.

15. One capsule three times daily.

16. Patient satisfaction • Quality: Arthroclem is manufactured in an FDA inspected facility we carry product liability. • We had no reported adverse reactions • The product has been sold for 12 years in the USA.

17. Testimony • Arthroclem- My grandfather has suffered with arthritis and severe knee pain for several years, and has gotten some temporary relief using other formulas.  After less that 2 weeks on Arthroclem, he called to tell that nothing he has taken before has ever worked as well or as quickly.  After 2 months, he is completely pain free. • Dr.T.Santucci Delray Florida 561-278-2005

18. Testimony • Another great success with Arthroclem. • I was with a golf pro who recently came to me for multiple joint pain.  After 3 days, he called to tell me that he already notices significant improvement in the joint pain, • Dr.T.Santucci Delray Florida 561-278-2005

19. Why Richard Clement Nutrition ? • My mission statement is to provide you with what I like to use in practice, at high quality and fair price. • I am available for product support and therapeutic questions. • I have twenty years of Medical practice, I have been a reviewer of several NIH CAM review committees

20. Why Richard Clement Nutrition ? • Products created by a Medical Doctor • FDA inspected facilities • 12 Years of satisfied users. • 1-877-438-3042 Fax 305-594-2174 • www.web-outpatients.com