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State-of-the-Art Biomedical Imaging at CIBM Lausanne

Explore the cutting-edge imaging technologies at the CIBM in Lausanne, focusing on neurosciences, metabolic diseases, and oncology. Mission to advance functional and metabolic imaging for disease mechanisms and treatment monitoring. Infrastructure for preclinical imaging with MRI in rodents and PET equipment. Proposed activities for MRPET development with design guidance, testing, and large-bore scanners for humans and rodents.

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State-of-the-Art Biomedical Imaging at CIBM Lausanne

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  1. centre d’imagerie biomedicale MR (and PET) imaging at the arc lemaniqueat the CIBM Rolf Gruetter, (coll. w/J. Varela) Laboratory for Functional and Metabolic Imaging (LIFMET) Institute of Complex Matter Physics (IPMC) Ecole Polytechnique Federale de Lausanne (EPFL) and Departments of Radiology, UNIGE, UNIL Biomedical Imaging Center (CIBM)of EPFL, UNIL, HUG, CHUV and UNIGE Fondation Jeantet www.cibm.ch Fondation Leenards

  2. CIBM: A brief synopsis • Mission:Advance state-of-the artfunctional and metabolic imaging&address important biomedical problemsusingmodel systems ranging from transgenic animals to human patients ("from mouse to man") • Disease Focus: • Neurosciences (Brain diseases) • Metabolic diseases (Diabetes) • Oncology • Research Focus: • Mechanisms of disease; • Disease onset prior to damage • Treatment monitoring/planning

  3. Infrastructure for preclinical imaging • MRI in rodents • Procedure is the same as in humans • No informed consent: • Anesthesia to avoid motion • Physiologic monitoring • Temperature • Blood gases, pHa • EtCO2 • Breathing • Blood pressure • Blood glucose, lactate • Blood sampling in the magnet • “Blind” anesthesia • Instrument monitoring • Problem of blood volume Lac C3

  4. APD-based animal PET Equipmentplus 30+ full-time staff 1st 7 Tesla active-shield 9.4 Tesla/310 1st 14 Tesla/260 MRI

  5. Proposed activities for MRPET @ CIBM • Design guidance (from the end-user) • PET component testing • Availability of large-bore (26cm) 14.1 Tesla scanner (allows placing of PET components into magnet) • Susceptibility effects, etc. • RF interactions • Large on-site RF lab with 3 full-time staff • Network analyzers, on-site component modifications possible • PET Prototype testing • Humans at 7 Tesla (68cm) • Rodents at 14.1 Tesla

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