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Microneedle Arrays

Microneedle Arrays. BME 281 Dr. Sun Margaret Franklin. What are Microneedle Arrays?. Small patches (less than a square inch) made up of small needles Deliver medicine to the skin rather than the muscle Better immune responses because the body encounters pathogens first on its surface.

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Microneedle Arrays

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  1. Microneedle Arrays BME 281 Dr. Sun Margaret Franklin

  2. What are Microneedle Arrays? • Small patches (less than a square inch) made up of small needles • Deliver medicine to the skin rather than the muscle • Better immune responses because the body encounters pathogens first on its surface

  3. History • First discovered in 1998 but become a much more common interest in recent years • First made out of silicon • Easy manufacturing process • Any shape • Any size

  4. How It’s Made • 4 types of microneedles • Made from many different types of materials • Plastic • Metal • Polymer • Glass • Ceramic

  5. Layers of Skin • Microneedle arrays are small and invasive • Pass through the epidermis layer of the skin, but do not enter the dermis • Doesn’t encounter the nerves, so no pain is present

  6. How it Works • Needles are dry- hard and sharp • Injected into the skin- body fluids surround needles and make them swell • The hard polymer that was on the inside turns into a soft material that keeps the skin open while the medicine is let out of the microneedle and into the body • The soft microneedle is then painlessly removed

  7. Simple and safe

  8. Why is This Better? • No pain • The needles can never accidently stick another body • Vaccines don’t need health clinics to administer the shot • No disposable procedure needed • Cost effective • No temperature control • Proper dosage • Greater quantities

  9. Future Microneedle capsules • Allow for oral delivery of large molecules Made up of • Drug reservoir • pH-sensitive coating

  10. References • S. Kaushik, A.H. Hord, D.D. Denson, D.V. McAllister, S. Smitra, M.G. Allen, M.R. Prausnitz Lack of pain associated with microfabricated microneedles Anesth. Analg., 92 (2001), pp. 502–504 • Hong, Xiaoyun, and Weien Yuan. "Hydrogel Microneedle Arrays for Transdermal Drug Delivery." Springer. N.p., 1 July 2014. Web. 20 Sept. 2015. • Trafton, Anne. "New Drug-delivery Capsule May Replace Injections." MIT News. N.p., 1 Oct. 2014. Web. 20 Sept. 2015. • Kim, Yeu-Chun, Jung-Hwan Park, and Mark R. Prausnitz. "Microneedles for Drug and Vaccine Delivery." Advanced Drug Delivery Reviews 64.14 (2012): 1547-568. Web

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