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How is Asian/Chinese Skin different for photodamage?

Overview of Ultraviolet Effects: Acute Damage Chronic Damage. How is Asian/Chinese Skin different for photodamage?. UVB. Direct DNA damage. UVA. ROS generation. Inflammatory Mediators. Inflammatory Mediators. UV Pathways to Skin Damage Damaging effects are 80% UVB/20% UVA.

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How is Asian/Chinese Skin different for photodamage?

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  1. Overview of Ultraviolet Effects: Acute Damage Chronic Damage How is Asian/Chinese Skin different for photodamage?

  2. UVB Direct DNA damage UVA ROS generation Inflammatory Mediators Inflammatory Mediators UV Pathways to Skin DamageDamaging effects are 80% UVB/20% UVA

  3. Inflammatory Mediators Inflammatory Mediators UV Pathways to Skin DamageDamaging effects are 80% UVB/20% UVA

  4. Matrix-degradingenzymes (MMP, etc) Enzymes Matrix-degradingenzymes (MMP, etc) Enzymes UV Pathways to Skin DamageDamaging effects are 80% UVB/20% UVA

  5. Matrix-degradingenzymes (MMP, etc) Enzymes Matrix-degradingenzymes (MMP, etc) Enzymes UV Pathways to Skin DamageDamaging effects are 80% UVB/20% UVA

  6. UV Pathways to Skin DamageDamaging effects are 80% UVB/20% UVA Matrix-degradingenzymes (MMP, etc) Enzymes

  7. Both UVA and UVB both lead to chronic photodamage UVB UVA • Direct DNA damage • Immune suppression • Mutations and skin cancer • Reactive Oxygen Species Inflammation • Pigmentation • Metalloproteineases • Collagen and elastin degradation • Sagging, wrinkles

  8. Chinese women 14 – 20 years old

  9. Indian women 14 – 20 years old Chinese women 14 – 20 years old

  10. Chinese women 65 - 75 years old

  11. Indian women 65 - 75 years old

  12. How is Asian/Chinese Skin different for photodamage? • Skin aging parameters start later than Caucasian1,2 with different patterns • Within Chinese population, skin aging parameters start earlier for higher UV exposure by approximately 10 years1 • Korean wrinkle formation is highly correlated with sun exposure3 • Pigment changes are different in Asian skin versus Caucasian with aging and photoaging1 • Photoaging differences are not all explained by differences in pigmentation • Zhao, P. Wang C. Solar ultraviolet Radiation and Skin Damage: An epidemiological study among a Chinese popoulation. Archives of Environmental Health, 53:6, 1998. • Chung, J.H. Photoaging in Asians. Photodermatology, Photoimmunology & Photomedicine. 19:109-121. 2003 • Chung, J.H. Et al. Cutaneous Photodamage in Koreans. Archives of Dermatology 137:1043-1051.

  13. Photodamage is not just about pigmentation and wrinkles Photograph courtesy of Robert & Margaret Weiss, MD

  14. Effects of UV on Photoaging:Conclusions • UV exposure induces photodamage and photoaging through several mechanisms • UVA can produce photoaging in the absence of UVB • In order to reduce photodamage, sunscreens must protect against both UVB and UVA Photograph courtesy of Robert & Margaret Weiss, MD

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