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Lec 15: AMINO ACID CATABOLISM

Lec 15: AMINO ACID CATABOLISM. fate of amino nitrogen in mammals. fig 18-1. metabolism of amino nitrogen in liver. fig 18-2. nitrogen removal molecules…. fig 18-2. metabolism of amino nitrogen in liver. fig 18-2. transamination reaction. pg 677. fig 18-5. chemistry of the PLP

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Lec 15: AMINO ACID CATABOLISM

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  1. Lec 15: AMINO ACID CATABOLISM

  2. fate of amino nitrogen in mammals fig 18-1

  3. metabolism of amino nitrogen in liver fig 18-2

  4. nitrogen removal molecules… fig 18-2

  5. metabolism of amino nitrogen in liver fig 18-2

  6. transamination reaction pg 677

  7. fig 18-5

  8. chemistry of the PLP aldehyde: Schiff base formation fig 18-5

  9. PLP reactions: decarboxylation, deamination, racemazation fig 18-6

  10. PLP reactions: the transamination two-step... fig 18-6

  11. oxidative deamination: from amino group to ammonia fig 18-7

  12. oxidative deamination: from amino group to ammonia genetic disorder from loss of GTP allosteric control… fig 18-7 NOT

  13. metabolism of amino nitrogen in liver fig 18-2

  14. glutamine as a carrier of NH3 from tissue to liver fig 18-8

  15. metabolism of amino nitrogen in liver fig 18-2

  16. shuttling of NH4+ from muscle to liver reminiscent of the Cori cycle, yes? actual fig 18-9

  17. the urea cycle as a method of safely disposing of all that NH3+ fig 18-19

  18. fig 18-10

  19. fig 18-10

  20. logic of the urea cycle: NH4+, aspartate, and CO2

  21. making a transferable carbamoyl group… fig 18-11

  22. transferring that carbamoyl group…

  23. transfering that carbamoyl group… ornithine citruline

  24. ATP adding a good leaving group… citruline

  25. using that good leaving group to do chemistry…

  26. using that good leaving group to do chemistry… fig 18-11

  27. production of arginine… arginine + fumarate

  28. arginine H2O ornithine urea!! liberation of urea…

  29. coupling between the “Krebs cycles” fig 18-12

  30. a signal for increased urea production… fig 18-13

  31. administering a synthetic allosteric regulator pg 689

  32. clinical biochemical strategy for removing ammonia… fig 18-14

  33. we must consume amino acids…

  34. catabolism of amino acids: (most) roads lead to the Krebs cycle fig 18-15

  35. one-carbon metabolism cofactors fig 18-16

  36. one-carbon metabolism cofactors fig 18-16

  37. fig 18-16

  38. amino acids are used to make many things fig 18-22

  39. diseases of amino acid catabolism fig 18-23

  40. an example: pheylketonurea or PKU fig 18-23

  41. an example: pheylketonurea or PKU aspartame fig 18-23

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