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Chemotherapy Induced Nausea and Vomiting- Prophylaxis of Delayed Phase of CINV. High Emetic Risk Days 2 and 3 after chemotherapy: dexamethasone (8mg IV) + aprepitant (80mg PO) Moderate Emetic risk Anthracycline + cyclophosphamide:
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Chemotherapy Induced Nausea and Vomiting- Prophylaxis of Delayed Phase of CINV High Emetic Risk • Days 2 and 3 after chemotherapy: dexamethasone (8mg IV) + aprepitant (80mg PO) Moderate Emetic risk • Anthracycline + cyclophosphamide: Days 2 and 3 after chemotherapy: aprepitant ( 80mg PO) • All other regimens of moderate emetic risk: Days 2–4 after chemotherapy: dexamethasone 8mg PO daily Or A Serotonin 5-HT3 inhibitor Ondansetron 8mg PO daily or twice daily Granisetron 1mg PO daily Dolasetron 100mg PO daily One kind of serotonin 5HT 3 inhibitor