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Do Now

Do Now. Complete Part 1 on your worksheets with a partner. A problem for you to solve: Given that you know the axon sends signals electrically, and that the synapse sends signals chemically, how would you change the electrical signal of the axon into a chemical signal at the synapse?

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Do Now

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  1. Do Now • Complete Part 1 on your worksheets with a partner. • A problem for you to solve: • Given that you know the axon sends signals electrically, and that the synapse sends signals chemically, how would you change the electrical signal of the axon into a chemical signal at the synapse? • Brainstorm mechanisms to solve this problem with a partner.

  2. From Electrical Signal to Chemical Signal Electrical Signal Chemical Signal

  3. Synaptic Transmission Electrical Signal

  4. Synaptic Transmission Electrical Signal

  5. The Stage: Presynaptic cell Synaptic Cleft Postsynaptic Cell

  6. The Characters: Voltage-gated Ca2+ channels Synaptic vesicles Neurotransmitters (NT) Action Potential Receptors Ca2+ sensitive proteins Reuptake Transporters

  7. How do the characters work together to complete synaptic transmission?Complete Part 2 of your worksheets with a partner.

  8. The Play: 1. Action Potential

  9. The Play: 2. Voltage-gated Ca2+ channels open. Ca2+ flows into cell Ca2+ 1. Action Potential

  10. The Play: 2. Voltage-gated Ca2+ channels open. Ca2+ flows into cell 3. Ca2+ sensitive proteins fuse synaptic vesicles to membrane, releasing NTs into synaptic cleft Ca2+ 1. Action Potential

  11. The Play: 2. Voltage-gated Ca2+ channels open. Ca2+ flows into cell 4. NTs bind to postsynaptic receptors. 3. Ca2+ sensitive proteins fuse synaptic vesicles to membrane, releasing NTs into synaptic cleft Ca2+ 1. Action Potential

  12. The Play: 2. Voltage-gated Ca2+ channels open. Ca2+ flows into cell 4. NTs bind to postsynaptic receptors. 3. Ca2+ sensitive proteins fuse synaptic vesicles to membrane, releasing NTs into synaptic cleft Ca2+ 1. Action Potential 5. Ion channels open on postsynaptic membrane, allowing ions to flow into cell.

  13. The Play: 2. Voltage-gated Ca2+ channels open. Ca2+ flows into cell 4. NTs bind to postsynaptic receptors. 3. Ca2+ sensitive proteins fuse synaptic vesicles to membrane, releasing NTs into synaptic cleft Ca2+ 1. Action Potential 5. Ion channels open on postsynaptic membrane, allowing ions to flow into cell. 6. Excess NTs are degraded by enzymes or pumped back into presynaptic cell.

  14. The Play: 2. Voltage-gated Ca2+ channels open. Ca2+ flows into cell 4. NTs bind to postsynaptic receptors. 3. Ca2+ sensitive proteins fuse synaptic vesicles to membrane, releasing NTs into synaptic cleft Ca2+ 1. Action Potential 5. Ion channels open on postsynaptic membrane, allowing ions to flow into cell. 6. Excess NTs are degraded by enzymes or pumped back into presynaptic cell.

  15. Does it matter which ions flow into the cell? Sodium (Na+) Calcium (Ca2+) Chloride (Cl-) Positive Positive Negative

  16. Synaptic Transmission Ca2+

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