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Bio 449 Lecture 26 – Renal Physiology II Nov. 10, 2010

Bio 449 Lecture 26 – Renal Physiology II Nov. 10, 2010. Readings Lectures 25-27: Chapters 19 & 20. Nephrons (cont ’ d) Urine formation Glomerular filtration Proximal tubule Loop of Henle & initial distal tubule End distal tubule & collecting duct

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Bio 449 Lecture 26 – Renal Physiology II Nov. 10, 2010

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  1. Bio 449 Lecture 26 – Renal Physiology II Nov. 10, 2010 Readings Lectures 25-27: Chapters 19 & 20 Nephrons (cont’d) Urine formation Glomerular filtration Proximal tubule Loop of Henle & initial distal tubule End distal tubule & collecting duct Mechanisms of reabsorption and secretion Counter-current multipliers Summary of nephron function Terms to Know Bowman's capsule Proximal tubuleLoop of HenleDescending limbThin ascending limbThick ascending limbDistal tubuleCollecting duct Glomerular filtrationGlomerular filtration rate (GFR) Tubular lumenApical or luminal membraneBasolateral membrane Counter-current multiplier

  2. Nephrons

  3. Secretion and reabsorption

  4. Urine Formation

  5. Overview of nephron function Distal tubule Peritubular capillaries Efferentarteriole Glomerulus Afferentarteriole Proximaltubule Bowman’scapsule KEY Collectingduct LoopofHenle To renalvein = Filtration: blood to lumen = Reabsorption: lumen to blood = Secretion: blood to lumen To bladder andexternal environment = Excretion: lumen to externalenvironment Fig. 19-1

  6. Glomerular filtration

  7. Renal corpuscle Thickascendinglimb ofloop ofHenle Efferentarteriole Bowman’scapsule Podocyte Proximaltubule Glomerularcapillary Afferentarteriole Lumen ofBowman’scapsule Fig. 19-5

  8. Podocytes Fig. 19-5

  9. Renal corpuscle Podocyte Lumen ofBowman’scapsule Glomerularcapillary Podocytefootprocesses Capillaryendothelium Mesangialcell Fig. 19-5

  10. Renal corpuscle Foot processof podocyte Filtration slit Pores inendothelium Basal lamina Capillarylumen Filteredmaterial Lumen ofBowman’scapsule Fig. 19-5

  11. Proximal tubule

  12. Loop of Henle & initial distal tubule

  13. End distal tubule & collecting duct

  14. Mechanisms of reabsorption and secretion

  15. Counter-current multipliers

  16. Summary of nephron function Distal tubule Peritubular capillaries Efferentarteriole Glomerulus Afferentarteriole Proximaltubule Bowman’scapsule KEY Collectingduct LoopofHenle To renalvein = Filtration: blood to lumen = Reabsorption: lumen to blood = Secretion: blood to lumen To bladder andexternal environment = Excretion: lumen to externalenvironment Fig. 19-1

  17. Summary of nephron function

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