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T h - Helper Cell B Cell Macrophage Neutrophil (alternative path) Mast Cell Platelets

Hematopoiesis from pluripotent stem cells to mature, differentiated, cellular effectors of immunity and more Richard A. Poirier for HHMI/Harvard Immunology Summer Project 2004. T h - Helper Cell B Cell Macrophage Neutrophil (alternative path) Mast Cell Platelets.

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T h - Helper Cell B Cell Macrophage Neutrophil (alternative path) Mast Cell Platelets

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  1. Hematopoiesisfrom pluripotent stem cells tomature, differentiated, cellular effectors of immunityand moreRichard A. Poirier for HHMI/Harvard Immunology Summer Project 2004

  2. Th- Helper Cell B Cell Macrophage Neutrophil(alternative path) Mast Cell Platelets Tc Cytotoxic Cell Dendritic Cell Neutrophil Eosinophil Basophil Erythrocyte Click on one of the following effector cells to see the sequence of different cells that lead to its production

  3. T - helper cell pathway

  4. Pluripotent Stem CellThis is the undifferentiated precursor to all of the blood cells, red and white, and other immune effector cells, and platelets.

  5. Lymphoid Stem CellDaughter cell of the Pluripotent Stem Cell, this cell will divide to produce progenitors to either B cell or T cell lines.

  6. T cell progenitor leaves the bone marrow and settles in the thymus; will produce Thymocyte cells in the thymus which can, in turn differentiate into T helper cells, T killer cells, or T memory cells

  7. The Thymocyte is located in the thymus and divides to produce mature T effector cells….. Th (helper)Tc (cytotoxic-killer) or Tm (memory)

  8. Th (helper) cell…when activated by an Antigen Presenting Cell like a macrophage with antigen, the Th cell will induce rapid growth of white blood cells which help fight infection

  9. Click HERE to return to menu

  10. Tc (cytotoxic/”killer”) cell pathway

  11. Pluripotent Stem CellThis is the undifferentiated precursor to all of the blood cells, red and white, and other immune effector cells, and platelets.

  12. Lymphoid Stem CellDaughter cell of the Pluripotent Stem Cell, this cell will divide to produce progenitors to either B cell or T cell lines.

  13. T cell progenitor leaves the bone marrow and settles in the thymus; will produce Thymocyte cells in the thymus which can, in turn differentiate into T helper cells, T killer cells, or T memory cells

  14. The Thymocyte is located in the thymus and divides to produce mature T effector cells….. Th (helper)Tc (cytotoxic-killer) or Tm (memory)

  15. Tc (cytotoxic or “killer”) Cells…Sometimes called CTLs (cytotoxic T lymphocytes, these may recognize infected “self” cells and destroy them.

  16. Click HERE to return to menu

  17. B cell pathway

  18. Pluripotent Stem CellThis is the undifferentiated precursor to all of the blood cells, red and white, and other immune effector cells, and platelets.

  19. Lymphoid Stem CellDaughter cell of the Pluripotent Stem Cell, this cell will divide to produce progenitors to either B cell or T cell lines.

  20. B Cell progenitor…found in the bone marrow of higher vertebrates and the Bursa of Fabricius in birds, these cells will produce antibody producing B cells.

  21. B Cells… these are found in the blood and , when activated will produce antibodies against particular antigens. Each cell produces antigen specific antibodies of only one type.

  22. Click HERE to return to menu

  23. Dendritic cell pathway

  24. Pluripotent Stem CellThis is the undifferentiated precursor to all of the blood cells, red and white, and other immune effector cells, and platelets.

  25. Myeloid Stem Cells… daughters of the Pluripotent Stem Cells, these are the progenitors of a host of specialized white blood cells (WBCs), red blood cells (RBCs) and the blood platelets which are crucial to blood clotting.

  26. Granulocyte -Monocyte Progenitor cells can differentiate into monocytes or neutrophils

  27. Monocytes… act as antigen presenting cells (APCs), as Antibody-Dependent Cytotoxic Cells (ADCC) , and promote inflammation.

  28. Dendritic Cell… like the macrophage, this cell is phagocytic it inhabits the tissues looking for foreign intruders to devour.

  29. Click HERE to return to menu

  30. Macrophage pathway

  31. Pluripotent Stem CellThis is the undifferentiated precursor to all of the blood cells, red and white, and other immune effector cells, and platelets.

  32. Myeloid Stem Cells… daughters of the Pluripotent Stem Cells, these are the progenitors of a host of specialized white blood cells (WBCs), red blood cells (RBCs) and the blood platelets which are crucial to blood clotting.

  33. Granulocyte -Monocyte Progenitor cells can differentiate into monocytes or neutrophils

  34. Monocytes… act as antigen presenting cells (APCs), as Antibody-Dependent Cytotoxic Cells (ADCC) , and promote inflammation.

  35. Macrophage…functions as antigen presenting cell (APC), in inflammation, and in ADCC (antibody-dependent cell-mediated cytotoxicity

  36. Click HERE to return to menu

  37. Neutrophil Pathway

  38. Pluripotent Stem CellThis is the undifferentiated precursor to all of the blood cells, red and white, and other immune effector cells, and platelets.

  39. Myeloid Stem Cells… daughters of the Pluripotent Stem Cells, these are the progenitors of a host of specialized white blood cells (WBCs), red blood cells (RBCs) and the blood platelets which are crucial to blood clotting.

  40. Granulocyte -Monocyte Progenitor cells can differentiate into monocytes or neutrophils

  41. Monocytes… act as antigen presenting cells (APCs), as Antibody-Dependent Cytotoxic Cells (ADCC) , and promote inflammation.

  42. Neutrophils…function in antimicrobial activity, inflammation response, and antibody-dependent, cell-mediated cytotoxicity (ADCC)

  43. Click HERE to return to menu

  44. Alternative Neutrophil pathway

  45. Pluripotent Stem CellThis is the undifferentiated precursor to all of the blood cells, red and white, and other immune effector cells, and platelets.

  46. Myeloid Stem Cells… daughters of the Pluripotent Stem Cells, these are the progenitors of a host of specialized white blood cells (WBCs), red blood cells (RBCs) and the blood platelets which are crucial to blood clotting.

  47. Granulocyte -Monocyte Progenitor cells can differentiate into monocytes or neutrophils

  48. Neutrophils…function in antimicrobial activity, inflammation response, and antibody-dependent, cell-mediated cytotoxicity (ADCC)

  49. Click HERE to return to menu

  50. Eosinophil Pathway

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