Cellular and extra cellular lesions II

1. Cellular and extra cellular lesions II

2. Steatosis (fatty change)From: Stevens A. J Lowe J. Pathology. Mosby 1995 Fig.4.1 Fig. 4.1 Causes of fatty change: diabete, malnutrition, toxic substances (alcohol), chronic hypoxia, over-feeding, etc. Cell poison (alcohol)=>reduced cell enzyme activity=>inability to metabolise fat=>fat cell accumulation

3. Hepatic steatosis Fig.4.2 Fig. 4.2. Fatty liver is enlarged and yellow

4. Hepatic steatosisFrom cases of the Pathology Department - U.M.F. “Gr. T. Popa” Iasi Fig.4.3

5. Fig.4.4 Fig.4.3-4. Fatty liver. Small and large unstained fat intracellular vacuoles with clear borders.

6. Hepatic steatosisFrom cases of the Pathology Department - U.M.F. “Gr. T. Popa” Iasi Fig. 4.5. Fig. 5. Fatty liver – HE: small and large clear vacuoles.

7. Fig. 4.6. Fig. 6. Black Sudan: intracellular lipid deposits are black stained

8. Localized hemosiderosisFrom cases of the Pathology Department - U.M.F. “Gr. T. Popa” Iasi Fig.4.7 Fig.7 HE-hemosiderin appears as a yellow brown granular pigment

9. Fig. 4.8. Fig.8. In Perls reaction, hemosiderin is blue in color.

10. Jaundice From: Stevens A. J Lowe J. Pathology. Mosby 1995 Fig. 4.9. Fig. 9. Icterus: yelow color of skin and sclerae.

11. Fig. 4.10. Fig. 10. In icterus, liver is greenish-yellow.

12. Jaundice From cases of the Pathology Department - U.M.F. “Gr. T. Popa” Iasi Fig. 4.11.

13. Fig. 4.12. Fig. 11-12. In hepatic icterus: (a) intrahepatocyte granular pigment - hepatocyte cytoplasm contains bilirubin as small greenish-brown granules. (b) billiary cylinder (billiary thrombi) - small biliary channels are distended through greenish-brown pigment; is a characteristic feature in cholestatic jaundice.

14. Hyalinosis of afferent glomerular arterioleFrom: Stevens A. J Lowe J. Pathology. Mosby 199 Fig. 4.13.

15. Fig. 4.14. From cases of the Pathology Department - U.M.F. “Gr. T. Popa” Iasi Fig. 13-14. Afferent arteriolewall hyalinosis, partial or total hyalinosis of glomeruli, and dilated renaltubules with hyaline plugs (thyroidization).

16. AmyloidosisFrom: Stevens A. J Lowe J. Pathology. Mosby 1995 Fig. 4.15.

17. Fig. 4.16.

18. Histology of renal amyloidosisFrom: Stevens A. J Lowe J. Pathology. Mosby 1995 Fig. 4.17.

19. Fig. 4.18.