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Meiosis

Meiosis. Introduction to Meiosis. Mitosis = reproduction of body cells ( SOMATIC CELLS) Meiosis = reproduction of sex cells (sperm and eggs )

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Meiosis

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  1. Meiosis

  2. Introduction to Meiosis • Mitosis= reproduction of body cells (SOMATIC CELLS) • Meiosis= reproduction of sex cells (sperm and eggs) • Sex Cells (GAMETES) = reproductive cells produced in sex organs (testes/ovaries) • Reduces chromosome number from DIPLOID (2n) down to HAPLOID (n)

  3. Hmmm? Body Cell • Why do sex cells have only half the genetic information of body cells? 46 46 46 92!

  4. Comparing Mitosis vs. Meiosis Mitosis Meiosis Sex Cells (egg and sperm) Two Divisions Creates 4 cells Copies has half the number of chromosomes 23 chromosomes in a sperm or egg cell NOT in pairs • Body Cells • One Division • Create 2 identical cells • Copies have the exact same number of chromosomes • 46 chromosomes in every body cell • Paired chromosomes

  5. Meiosis Overview • Meiosis Overview Video Chromosomes Chromatids

  6. (mom) 23 + (dad) 23 = (you!) 46 chromosomes • All male sperm is genetically different from one another • All female eggs are genetically different from one another • When they fuse in fertilization, the chromatids combine to make a new individual!

  7. Homologous Chromosomes • HOMOLOGOUS (“same”) pairs of chromosomes = same sized chromosomes that carry the same genes

  8. Meiosis I – First of 2 Divisions Prophase I • Chromosomes coil up and become visible • Nuclear membrane and the nucleolus disappear • Spindle fibers form • Centrioles begin to move to opposite sides • HOMOLOGOUS CHROMOSOMES pair up and CROSSING OVER occurs.

  9. Meiosis I Crossing over • Chromosomal material is exchanged between sister chromatids • Allows for genetic variation! • Then, paired chromosomes line up in the center for metaphase I

  10. Meiosis I ANAPHASE I Homologous chromosomes split and move to opposite ends This is where the chromosome number is divided in half (2n  n)

  11. Meiosis I Telophase I • Cleavage furrow forms • Cytokinesis occurs • Nuclear membrane DOES NOT reform • Chromosomes DO NOT go back to chromatin • 2 daughter cells have been created with the haploid number of chromosomes • Meiosis I Animation

  12. Meiosis II – Mitosis in each daughter cell • Centrioles move apart • Spindle forms between centrioles • Sister chromatids line up in the middle of cell • Fibers pull sister chromatids apart • Nuclear membrane and nucleolus reform • Cell membrane pinches in and divides in the cytoplasm • End Result: 4 sex cells (different than what started out with!!)

  13. Meiosis II - Review

  14. Why is Meiosis Important? • Keeps the number of chromosomes the same from one generation to the next • Human sperm cell + Human egg cell= zygote • 23 chromosomes + 23 Chromosomes= 46 chromosomes • Provides genetic variation • Why you don’t look exactly like your siblings

  15. Meiosis Animations • http://www.cellsalive.com/meiosis.htm • http://www.youtube.com/watch?v=D1_-mQS_FZ0&feature=related • http://www.youtube.com/watch?v=MyXvx5FkfTE&feature=related

  16. Karyotype – All of the chromosomes in the nucleus of each cell • Can you find the homologous pairs? • How many homologous pairs do you see?

  17. Meiosis: Males vs. Females • Males – Meiosis is called SPERMATOGENESIS • 4 equally sized sperm produced • Cytoplasm divides evenly • Ongoing in testes throughout a male’s life • Human males produce approximately 1000 sperm per second (30 billion/year).

  18. Meiosis: Males vs. Females • Females – Meiosis is called Oogenesis • 4 cells, but only 1 becomes an egg • Uneven cytokinesis – 1 cell receives most of the cytoplasm = EGG (needs extra cytoplasm to accommodate fertilization) • Other 3 cells receive very little cytoplasm and die off = POLAR BODIES

  19. Meiosis: Males vs. Females • Meiosis in human females begins before person is born but stops in prophase I and does not resume until after puberty. • Each month, approximately 1000 primary oocytes will mature but most will die. • Ovulation occurs approximately once every 28 days. Females ovulate approximately 400 times during their lifetime • Women are born with all of the primary oocytes that they will ever have (2 million). At puberty, there are approximately 400,000 left.

  20. Final Comparison – Mitosis vs. Meiosis • Compare Mitosis and Meiosis • http://www.pbs.org/wgbh/nova/miracle/divi_flash.html

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