Ceftriaxone & Sulbactam Injection & Ringer Lactate Infusions manufacturer supplier & exporter in India (

2. Ceftriaxone & Sulbactam Injection manufacturer, supplier & exporter in India • JoinhubPharmais a WHO-GMP & EU-GMP certified Ceftriaxone & Sulbactam Injection manufacturer, supplier & exporter based in India. JoinHub Pharma’s Ceftriaxone & Sulbactam Injection are GMP certified and are manufactured in our manufacturing facilities located in India. • We have a WHO-GMP manufacturing pharma factory located in Ahmedabad, Gujarat, India. According to international regulatory guidelines, the EUGMP-approved plant in India is built and also approved by WHO-GMP, EU-GMP, MOH of different countries, and other regulatory agencies.

3. Ceftriaxone & Sulbactam Injection • Product Features:- • Dosage: 1gm/500mg • Therapy: Bacterial Infection • Active Ingredients: Ceftriaxone and Sulbactam

4. General Information: • JoinHub Pharma is a popular manufacturer, supplier and exporter of Ceftriaxone & Sulbactam Injection in India. • Ceftriaxone+Sulbactam injection is essential to cure bacterial infections. This medication consists of Ceftriaxone and Sulbactam. Among these two ingredients, Ceftriaxone is a type of antibiotic. As an antibiotic, Ceftriaxone stops any bacterial growth from spreading further.

5. Side Effects: • The usual side effects seen after administration of ceftriaxone injection include pain and swelling at the site where the injection is administered, skin rash, diarrhoea, nausea, vomiting and black stools. However, if any of these symptoms are persistent or if they worsen over the period of time, consult your healthcare provider immediately. • Additional Information:- • The Ceftriaxone & Sulbactam Injection is usually prescribed for certain infections caused by Ceftriaxone sodium-sensitive pathogens. In terms of the clinical settings, this sulbactam injection is used in Sepsis, Meningitis, Abdominal Infections (e.g. Peritonitis, infection of the biliary tract), infections of the Bones, Joints, Soft tissue, wounds of the skin, Renal and Urinary Tract Infections, Respiratory tract Infections, particularly Pneumonia, and Ear, Nose and Throat Infections, and uncomplicated gonorrhoea. In addition to that, Ceftriaxone & Sulbactam for Injection may also be used for Perioperative Prophylaxis of • Infections. In terms of dosage, a single dose may be given before an operation. This is helpful in terms of avoiding any chances of complications arising in terms of infections Post Operation.

6. Precautions: • In order to prevent the risk of any development of bilirubin encephalopathy, use of Ceftriaxone & Sulbactam Injection is generally avoided especially in neonates in general and also prematures in particular. When the treatment of Ceftriaxone & Sulbactam Injection is prolonged for a certain period of time, the patient’s blood profile should be checked at regular intervals of time. Moreover, the dosage adjustments are usually not necessary in hepatic failure. However, in patients with hepatic dysfunction and significant renal malfunction, Ceftriaxone & Sulbactam Injection doses must maintain a limit. This limit • should not exceed an equivalent of 2g/day of Ceftriaxone. In fact, close serum monitoring is also an optimal option. The individuals who are sensitive to penicillin extreme caution needs to be exercised regularly. Those cases that show hypersensitivity reactions, should consider taking emergency measures like consulting your healthcare professional. When there is any allergic reaction, it usually means there is some interruption in the therapy of Ceftriaxone & Sulbactam Injection. Additionally, Ceftriaxone & Sulbactam Injection should not be administered to neonates in general, also hyperbilirubinemia neonates in particular, and to premature babies.

7. Administration and Dosage: • Your doctor will guide you accurately in terms of the dosage for lidocaine injection and one should not exceed it. • Skilled Workforce • Over a period of time, there was no sight of impairment of renal function even after taking large doses of Ceftriaxone and potent diuretics. There is no information which supports that Ceftriaxone increases renal toxicity of aminoglycosides. Moreover, when The Ceftriaxone is eliminated, it is not altered by probenecid. Studies prove that Ceftriaxone and chloramphenicol are antagonistic in in vitro studies. When the case of concomitant severe renal and hepatic dysfunction arises, the plasma concentrations of

8. ceftriaxone should be determined at regular intervals. Remember that Coombs’ test may show false-positive results while undergoing Ceftriaxone therapy. Moreover, non-enzymatic urinary glucose estimation methods may also give false-positive results. In terms of reproductive studies of ceftriaxone have been performed in mice and rats at very high doses. As a result, no evidence of embryotoxicity, fetotoxicity or teratogenicity was observed. However, in absence of adequate and well-controlled studies in pregnant women, and since reproductive animal studies may not always show true human response, this drug should be used during pregnancy only if it is clearly needed. As ceftriaxone is secreted in the breast-milk, even though at a low concentration, caution should be exercised during its administration in nursing mothers.

9. Overdose: • As of now, very limited information is available on the acute toxicity of Ceftriaxone & Sulbactam Injection. Moreover, no specific antidote is available for treating overdose. In addition, Hemodialysis does not remove the drug from the system effectively. Hence, the treatment for Ceftriaxone & Sulbactam for Injection overdose is essentially supportive and symptomatic. Consult your healthcare expert immediately in the case of adverse reactions. • Adverse Reactions: • The following side effects are reported to occur during Ceftriaxone therapy and may be seen when it is administered with the combination as well. These reactions include- Gastrointestinal namely Diarrhoea, nausea & vomiting (less frequent), stomatitis, and glossitis. In terms of Hepatic, Elevations of SGOT/SGPT. While in the case it is Haematological, Eosinophilia, thrombocytopenia, leukopenia, granulocytopenia, hematoma or bleeding. However, Hemolytic anaemia is observed less frequently. Moreover, Agranulocytosis (< 500/mm 3) has been reported occasionally at a total cumulative dose exceeding 20 g. In terms of skin reactions, Exanthema, allergic dermatitis, pruritus, urticaria, edema, erythema multiforme is seen. Various other side effects such as headache, dizziness, increase in serum creatinine, mycosis of the genital tract, oliguria, fever, and shivering have been seen as well. In the case when Anaphylactic shock occurs, it will require immediate counter-measures.

10. Ringer Lactate Infusions manufacturer, supplier & exporter in India • JoinHub Pharma, an India-based company, specializes in manufacturing, supplying, and exporting WHO-GMP and EU-GMP certified Ringer Lactate Infusions. • Our manufacturing facilities in India produce GMP certified Ringer Lactate Infusions, adhering to stringent quality standards. Located in Ahmedabad, Gujarat, our WHO-GMP approved plant is built in compliance with international regulatory guidelines. It holds approvals from WHO-GMP, EU-GMP, MOH of various countries, and other regulatory agencies. Choose JoinHub Pharma for reliable and compliant Ringer Lactate Infusions.

11. Ringer Lactate Infusions Product Features:- Dosage: 500ml Therapy: Intravenous Rehydration Active Ingredients: Sodium Chloride, Potassium Chloride, Sodium Lactate, Calcium Chloride

12. General Information: • Ringer Lactate Infusions are primarily used for electrolyte replacement due to its property of being non-pyrogenic and sterile solutions. However, in absence of any antimicrobial agents, this infusion is not useful in treating any form of microbial infections. • Side Effects: • Some common unwanted reactions as seen after this infusion are given down below- • Nausea • Numbness • Tingling sensation • Allergies • Cardiac toxicity

13. Chest pain • Anxiety • Confusion • Diarrhoea • Altered heart rate • Black and bloody stools • Muscle weakness • Muscle paralysis • Stomach cramps • Abdominal swelling • Vomiting • Weakness

14. Additional Information:- • Indications and Usage: • This medication is additionally useful in treating burns, gastrointestinal fluid loss as well as any form of acute blood loss. The dosage of this IV infusion is dependent on the severity of the condition, weight, age and gender of the patient. Individuals should always consult a healthcare expert before starting a treatment through Ringer Lactate Infusions. • Precautions: • Never use this medication if: • You have had a history of kidney failure. With the presence of potassium in it, it may lead to adverse situations and cause hyperkalemia or high potassium levels. • You have allergic reactions such as anaphylaxis and anaphylactic reactions • You presently have a liver condition • You are diagnosed with acidosis or alkalosis so taking this medication may simply cause electrolyte imbalance in the body • In order to access a detailed list of all possible consequences after this durg, consult a medical professional.

15. Administration and Dosage: • This solution should be very slowly infused with the help of a small bore needle inserted properly within the lumen of a large vein to decrease any form of irritation. Your medical expert will also ensure no infiltration to occur thereby monitoring blood glucose levels, electrolyte concentrations, fluid and electrolyte balance during the prolonged course of treatment. • Interactions: • Any pharmaceutical when it comes into contact with other drugs can cause adverse conditions. Some of these possible drugs are listed down below- • Eplerenone • Alacepril • Amiloride • BaloxavirMarboxil • Benazepril • Bictegravir

16. Canrenoate • Captopril • Cilazapril • Delapril • Digoxin • Eltrombopag • Erdafitinib • Fosinopril • Imidapril • Indomethacin • Lisinopril • Moexipril • PentoprilPerindopril • Quinapril • Raltegravir

17. Ramipril • Spirapril • Spironolactone • Temocapril • Trandolapril • Triamterene • Zofenopril • Chlorothiazide • Delafloxacin • Licorice • Strontium Ranelate

18. Overdose: • If any individual is overdosed from Ringer Lactate Infusions, they may show excessive fluid and sodium levels within the body. This may lead to edema of peripheral or pulmonary especially when renal sodium excretion fails. This overload can also cause metabolic alkalosis. Therefore, in this situation contact your emergency department immediately. • Adverse Reactions: • This infusion can possibly show signs of adverse condition in patients with congestive heart failure or edema because of sodium overload. Therefore, these patients should be refrained from giving Ringer Lactate Infusion and they should visit the nearest hospital in any serious situation.

19. Contact Us Today For All Your Requirement Related To Pharmaceutical Products www.joinhubpharma.com info@joinhubpharma.com +91 97247 25604 A/204, Siddhi Vinayak Business Park, Nr.kataria Automobiles Ltd, Makarba. S.G.Road, Ahmedabad-380051 Gujarat (India).