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Injectable drug delivery systems

Injectable drug delivery systems. R. Dinarvand, PhD Professor of Pharmaceutics. Injection routes. Intravenous (I.V.) Immediate availability of drugs Constant level difficult Size limitation RES uptake Intramascular (I.M.) Very common Slow release Subcutaneous (S.C.) Similar to I.M.

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Injectable drug delivery systems

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  1. Injectable drug delivery systems R. Dinarvand, PhD Professor of Pharmaceutics

  2. Injection routes • Intravenous (I.V.) • Immediate availability of drugs • Constant level difficult • Size limitation • RES uptake • Intramascular (I.M.) • Very common • Slow release • Subcutaneous (S.C.) • Similar to I.M. • Slower release

  3. Injectable systems • Traditional formulations • Oil solvents • Less soluble salts • Particulate systems • Lipid based • Liposomes • Polymeric systems • Nanoparticles • microparticles • In situ gel forming systems • Erythrocytes • Bioconjugates

  4. Polymeric systems • Biodegradable polymers • Nano for IV administration • Less as drug depo • Mainly as targeting agents • Surface treatment • MAB • PEG • Folate • Transferin

  5. Conjugates • Albumin • Hyalorunic • PLGA • PEG • MAB

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