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xigris/200-sepsis-management-challenges.jsp

Introduction. http://www.xigris.com/200-sepsis-management-challenges.jsp. Invasive Infection. Immune Cells and Cytokines. http:// blogs.cgdev.org/globalhealth/under_5_deaths.gif. HMGB1 Release. Receptor Binding Toll- Like Receptor RAGE Dual Knockout Receptor. TNF Release.

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xigris/200-sepsis-management-challenges.jsp

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  1. Introduction http://www.xigris.com/200-sepsis-management-challenges.jsp Invasive Infection Immune Cells and Cytokines http://blogs.cgdev.org/globalhealth/under_5_deaths.gif HMGB1 Release Receptor Binding Toll- Like Receptor RAGE Dual Knockout Receptor TNF Release http://www.uic.edu/classes/bios/bios100/lecturesf04am/inflammation01a.jpg High Mobility Group Box-1 • Pro-Inflammatory • Protection- Critical Illness • Normal –Lethal Response • Appears in 16-24 hrs • Plateaus 24-32 hrs • Late Action-Therapeutic Target in Inflammation ELISA Capture Sample Detection Secondary Substrate Yang (2005) • Cytokines and Proteins linked to Sepsis-HMGB1 • Normal/ Septic Conditions. • TLR4, TLR2, RAGE. • Single Knockout Receptors Purpose To determine the effectiveness of the dual knockout receptors T2R and TR4, in lowering TNF levels as compared to single knockout receptors. Yang, 2005 Hypothesis 2 Hypothesis 1 Dual knockout receptor cells will have similar TNF levels as compared to each other and single knockout receptor cells, when exposed to all HMGB1 and LPS concentrations. The dual knockouts will have the lowest TNF levels in both the HMGB1 and TNF Trials.

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