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Produced by Huh Jae-won

Produced by Huh Jae-won. 구조 : 특이점은 가상의 코팅지역을 만들었다. 분포와 삽입된 구조. LTR 을 기존의 Repbase 에 있는것보다 더 보강해서 컨센선스 서열을 만들었다. 진화적 분석과 삽입시기. Retroelement(HERV-M) contribute to the diversification of PPHLN1 gene during the Primate evolution. Expression Profiling of HERV-M related alternative transcript.

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Produced by Huh Jae-won

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  1. Produced by Huh Jae-won

  2. 구조: 특이점은 가상의 코팅지역을 만들었다.

  3. 분포와 삽입된 구조

  4. LTR을 기존의 Repbase에 있는것보다 더 보강해서 컨센선스 서열을 만들었다.

  5. 진화적 분석과 삽입시기

  6. Retroelement(HERV-M) contribute to the diversification of PPHLN1 gene during the Primate evolution

  7. Expression Profiling of HERV-M related alternative transcript Brain Prostate Testis Kidney Heart Liver Lung Placenta Ske-M Spleen Thymus Uterus Human Chimp Go Or Gi Rhesus Hu AT Hu Bo Rhe AT Rhe Bo Cord B Rhe Hi 1 2

  8. Human Chimpanzee Gorilla Orangutan Gibbon Old World monkeys New World monkeys Prosimians Million years 60 50 40 30 20 10 Evolution of PPHLN1 related HERV-M Divergence : 10%(±1.5%)

  9. HERVM LTR pol gag LTR IN RT RnaseH 5’ LTR 3’ LTR 1 458 620 1338 1461 2215 2644 3050 3818 4038 1 458 PBS 3928 3967 4038 1 458 1 77 3402 3626 Splicing of HERV-M

  10. Aligment of PPHLN1 Transcripts

  11. The Structure of PPHLN1 Gene LTR5B MER58A HERV-M Orthologous region Human 1 2 3 4 5 6 7 8 9 10 11 12 13 14 Transcript variant 1 Transcript variant 2 Transcript variant 3 Transcript variant 4 Transcript variant 5 Alusq/x VS L1ME4a Transcript variant 1 AluJo Transcript variant 2 Mouse 1 2 3 4 5 6 7 8 9 10

  12. (Retroelements : Alu, Line, HERV) Hu1 Hu2 Hu3 Hu4 Type 1 transcript Mu1(Duplication) Common ancestor Hu5 Type 2 transcript Mu2 Evolution of PPHLN1 transcripts Driving Forces PPHLN1 gene

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