1 / 28

Core 3.1 - Dartmouth Activities

NA-MIC National Alliance for Medical Image Computing http://na-mic.org. Core 3.1 - Dartmouth Activities. Andrew J. Saykin, Psy.D., ABPP-CN John D. West, M.S. Robert M. Roth, Ph.D. Brain Imaging Laboratory Dartmouth Medical School / DHMC . Overview. Volumetric ROI studies

josephine
Download Presentation

Core 3.1 - Dartmouth Activities

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. NA-MIC National Alliance for Medical Image Computing http://na-mic.org Core 3.1 - Dartmouth Activities Andrew J. Saykin, Psy.D., ABPP-CN John D. West, M.S. Robert M. Roth, Ph.D. Brain Imaging Laboratory Dartmouth Medical School / DHMC

  2. Overview • Volumetric ROI studies • Diffusion tensor imaging • ROI analyses • Tractography • Functional magnetic resonance imaging • Planned applications • Related work • Current Collaborations National Alliance for Medical Image Computing http://na-mic.org

  3. ROI Volumetric Studies • Manual Tracing and 3D Modeling of • ROIs using Slicer • ROIs: • Hippocampus • Amygdala • Entorhinal cortex • Caudate nucleus • Putamen • Nucleus accumbens • Thalamus • Fornix • Mammillary bodies National Alliance for Medical Image Computing http://na-mic.org

  4. ROI Volumetric Studies Illustration of 2D Traces and 3D Models of ROIs National Alliance for Medical Image Computing http://na-mic.org

  5. Diffusion Tensor Imaging FA in Uncinate Fasciculus ROI in Schizophrenia using Slicer Based on Kubicki et al., 2002 National Alliance for Medical Image Computing http://na-mic.org

  6. Diffusion Tensor Imaging Integration of Corpus Callosum Subregion ROIs with Tractography Healthy Control Patient with Schizophrenia C1 - rostrum and genu C2 - anterior truncus C3 - middle truncus C4 - posterior truncus C5 - isthmus and splenium [Wang et al. 2005] National Alliance for Medical Image Computing http://na-mic.org

  7. Functional MRI • Cognitive Task Development and Validation: Probing Frontal-Temporal Circuitry • Primary Tasks: • Working memory • Episodic memory • Semantic memory Secondary Tasks (other Circuitry) • Self-reflection • Reward • Planning National Alliance for Medical Image Computing http://na-mic.org

  8. Functional MRI Prospective Data Collection on 1.5T Magnet: Interim Analysis of Patients with Schizophrenia and Controls Controls Patients p (n=8) (n=13) Age (yrs.) 30.8 (7.1) 36.4 (10.3) NS Educ (yrs.)* 16.9 (2.4) 14.6 (1.9) .05 Sex (M,F) 3, 5 9, 3 NS WRAT Reading 111.5 (4.7) 105.0 (10.5) NS CVLT-II Total 1-5 58.4 (6.4) 38.6 (10.4) .001 * matched for parental SES National Alliance for Medical Image Computing http://na-mic.org

  9. Functional MRI n-Back Working Memory Task National Alliance for Medical Image Computing http://na-mic.org

  10. Functional MRI – Behavioral Performance Interim analysis National Alliance for Medical Image Computing http://na-mic.org

  11. Functional MRI FMRI Activation During 3-Back in Schizophrenia Simple Effects Controls N = 8 Patients N = 12 p = .01 Interim analysis National Alliance for Medical Image Computing http://na-mic.org

  12. Functional MRI FMRI Activation During 3-Back in Schizophrenia Controls > Patients Patients > Controls p = .01 Interim analysis National Alliance for Medical Image Computing http://na-mic.org

  13. Functional MRI Verbal Encoding/Retrieval Episodic Memory Task National Alliance for Medical Image Computing http://na-mic.org

  14. Functional MRI – Behavioral Performance Verbal Encoding/Retrieval Episodic Memory Task Interim analysis National Alliance for Medical Image Computing http://na-mic.org

  15. Functional MRI – Behavioral Performance Verbal Encoding/Retrieval Episodic Memory Task Interim analysis National Alliance for Medical Image Computing http://na-mic.org

  16. Functional MRI Verbal Encoding/Retrieval Episodic Memory Task FMRI Activation During Continuous Auditory-Verbal Memory (new > old word contrast) in Patients with Schizophrenia Patients N = 7 p = .01 Interim analysis National Alliance for Medical Image Computing http://na-mic.org

  17. Collaborations and Progress • Shape Analysis with UNC Group: Martin Styner, Guido Gerig • Hippocampal Shape - Dartmouth Data: SPHARM Left Mean Right Mean Overall Mean Skeleton-based subdivision http://www.na-mic.org/Wiki/index.php/Progress_Report:Shape_Analysis National Alliance for Medical Image Computing http://na-mic.org

  18. Collaborations and Progress • fMRI in Slicer – fMRIEngine - Wendy Plesniak and Haiying Liu • Met Dec. 14th, 2005 to discuss progress and future improvements to be made • Have supplied motor data from two controls to test results from module and compare with results from SPM2 • fMRI tasks – Brigham group • Porting of our tasks to BWH • Meeting with Marek Kubicki on Dec. 20th, 2005 to demonstrate our tasks and how we utilize them • Training session at BWH • Tara McHugh visited to get in depth training in Slicer for tracing structures – Dec. 1st, 2005 National Alliance for Medical Image Computing http://na-mic.org

  19. Collaborations and Progress • Working with Steve Pieper to test 64-bit Linux version of Slicer • Worked with Steve Pieper, Gordon Kindlmann, Xiaodong Tao, and Josh Snyder to convert Dartmouth DTI data to nrrd format and solve lingering orientation issues • DTI Path of Interest – MGH – David Tuch and Josh Snyder • Dartmouth request for tools to help relate DTI fiber tract pathways to connections in fMRI identified circuits • Collaboration to implement DTI Path of Interest Program at Dartmouth site • Successful initial results on NAMIC01 healthy control by both Josh Snyder at MGH and John West at Dartmouth • Plans: integrate functional ROIs derived from fMRI tasks National Alliance for Medical Image Computing http://na-mic.org

  20. DTI Path of Interest – Initial Results • Collaboration with David Tuch & Josh Snyder (MGH) • Description – program finds the optimal path between two or more ROIs using probability statistics • Implementation • C-code, Matlab and FSL scripts to generate optimal path • Slicer for visualization and tracing of input ROIs • Full implementation in Slicer as module is a future project • Initial results from NAMIC01 healthy control National Alliance for Medical Image Computing http://na-mic.org

  21. DTI Path of Interest – Initial Results Hippocampal ROI to Ventral Prefrontal ROI Uncinate Fasciculus National Alliance for Medical Image Computing http://na-mic.org

  22. DTI Path of Interest – Initial Results Receptive Speech Area ROI to Expressive Speech Area ROI Arcuate Fasciculus National Alliance for Medical Image Computing http://na-mic.org

  23. DTI Path of Interest – Initial Results Hippo ROI to Expressive Speech Area ROI Using Receptive Speech Area ROI as Guide Arcuate Fasciculus National Alliance for Medical Image Computing http://na-mic.org

  24. Planned Applications & Developments • Integration of fMRI and DTI data, including tractography (see tool “wish list”) • Effective and functional connectivity during cognitive tasks (see tool “wish list”) • Examine structural (ROI, DTI) and functional (fMRI) correlates of symptoms and cognition • Expand use of methods to other populations • bipolar disorder, OCD, MCI/AD, MS, TBI, epilepsy, other disorders National Alliance for Medical Image Computing http://na-mic.org

  25. Neuroimaging Research Center 3T Magnet National Alliance for Medical Image Computing http://na-mic.org

  26. Neuroimaging Research Center 3T Magnet National Alliance for Medical Image Computing http://na-mic.org

  27. Brain Imaging Laboratory: People FACULTY PIs (Psychiatry): • Laura A. Flashman, Ph.D. • Alan I. Green, M.D. • Thomas W. McAllister, M.D. • Brenna C. McDonald, Psy.D. • Robert M. Roth, Ph.D. • Andrew J. Saykin, Psy.D. • Heather A. Wishart, Ph.D. POST-DOCTORAL FELLOWS: • Howard Cleavinger, Ph.D. (Epilepsy) • Ellen Crouse, Ph.D. (MCI, chemotherapy) • Nancy Koven, Ph.D. (Schizophrenia) • Nadia Paré Ph.D. (MCI, ADNI) • Jo Cara Pendergrass, Ph.D. (Schizophrenia) KEY TECHNICAL COLLABORATORS: • Konstantinos Arfanakis, Ph.D. (DTI; IIT) • Fillia Makedon , Ph.D. (Computer Science) • James C. Ford, Ph.D. (Computer Science) • Li Shen, Ph.D. (CS, UMASS-Dartmouth) • Jason Moore, Ph.D. (Comp Genetics) BIL COORDINATOR • Heather Pixley, B.A. IMAGE ANALYSTS & SYSTEMS ADMIN: • John MacDonald, M.A. • Tara McHugh, M.A. • Paul Wang, B.A. • John West, M.S. STUDY COORDINATORS: • Mary Hynes, RN (TBI) • Ariel Rosen, B.A. (MS) NEUROSCIENCE TECHNICIANS: • Carrie Kruck, B.A. (chemotherapy) • Margaret Nordstrom, B.A. (MCI) RESEARCH MRI TECHNOLOGISTS: • Jorge A. Forero • Alice E. Davison National Alliance for Medical Image Computing http://na-mic.org

  28. Dartmouth Brain Imaging Laboratory December, 2005 National Alliance for Medical Image Computing http://na-mic.org

More Related