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HIV and T Cells

HIV and T Cells. Luci Davidson Nabeel Parwez Peter Komar Chris Ostrander. Helper T cell Infected with HIV. The Helper T cell is shown in green, the virus is shown in red. HIV Life Cycle. Virus binds to CD4 protein on helper T cells Fuses with cell membrane

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HIV and T Cells

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  1. HIV and T Cells Luci Davidson Nabeel Parwez Peter Komar Chris Ostrander

  2. Helper T cell Infected with HIV The Helper T cell is shown in green, the virus is shown in red.

  3. HIV Life Cycle • Virus binds to CD4 protein on helper T cells • Fuses with cell membrane • Empties contents into cell • reverse transcriptase copies viral genetic material from RNA into double-stranded DNA • integrase splices into cellular DNA • cell makes viral proteins and RNA using provirus • HIV protease cleaves new proteins • new proteins join RNA in new viral particles • particles bud from cell and infect others

  4. HIV Life Cycle

  5. Types of T Cells HIV binds to CD4, but not CD8. Therefore, only Helper T cells are affected.

  6. Course of Infection • rise of virus in blood which produces a drop in CD4 helper T cells • immune system recovers slightly, but HIV levels remain steady for several years • when CD4 T cell level drops below 200 cells per cubic mm blood, AIDS is diagnosed

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