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Surgery Trauma Burns Sepsis Radiation Chemicals Toxins

The Universal Theory of Medicine of Hans Selye. The Stress Repair Mechanism (SRM). COGNITIVE PATHWAY. Visual, Olfactory Auditory, Tactile. Cerebral Cortex. HPA Axis. CAPILLARY GATE COMPONENT Stressful Stimuli Intravascular Neurons Pathways. TISSUE REPAIR COMPONENT. Surgery Trauma

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Surgery Trauma Burns Sepsis Radiation Chemicals Toxins

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  1. The Universal Theory of Medicine of Hans Selye The Stress Repair Mechanism (SRM) COGNITIVE PATHWAY Visual, OlfactoryAuditory, Tactile Cerebral Cortex HPA Axis CAPILLARY GATE COMPONENTStressful StimuliIntravascularNeurons Pathways TISSUE REPAIR COMPONENT Surgery Trauma BurnsSepsisRadiationChemicalsToxins Anesthesia EmotionalMechanisms StressfulForcesExtravascularTissue Disruption EpinephrineNorepinephrineCortisol Hypothalamus Pain SYMPATHETIC Internuncial Nociception VASCULARENDOTHELIUM PARASYMPATHETIC Krebs Cycle Spinal Cord Tissue Factor Pathway InhibitorATIIIProtein C Insulin NitricOxide ThrombinAmplificationFactor IX Peripheral Nerves ATP Ca+ ThrombinAcceleration Analgesia Thrombin Activation TISSUE FACTOR PAI TPA Factor VII THROMBIN Factor VIIIC VON WILLIBRAND FACTOR PeripheralReceptors TAFI FIBRONIGEN Factor X Sensory Stressors FibrinSplit Products Insoluble Fibrin SOLUBLEFIBRIN Factor XIII SPINAL PATHWAY Fibronectin Vitronectin TISSUEREPAIR COAGULATION PlateletsInflammationChemotaxisMitosis SYSTOLICTURBULENTRESISTANCE PusScabsCastsExudates Abscesses CAPILLARYFLOW CAPILLARYHEMOSTASIS SYSTOLICLAMINARFLOW TemperatureCatabolismFeverImmune CellsEndotheliumOsteoblastsMyoblastsFibroblastsCollagen ImmuneProteins MetabolismAngiogenesisChemokinesCytokinesProstaglandins Malignancy Apoptosis HyperviscosityHypercoagulableFlow ResistanceIncreased SWR Cardiac WorkHypertensionDecreased CO Atherosclerosis Optimal ViscosityNormocoagulableFlow FacilitationDecreased SVRCardiac RestHypertensionIncreased COHealth & Longevity Tissue PerfusionHyperoxemiaOrgan ActivityDecreased SVROrgan PreservationHypotensionIncreased CODecreased HR Tissue IschemiaHypoxemiaOrgan QuiescenceIncreased SWROrgan StressHypertensionDecreased COIncreased HR BoneMuscle PneumoniaInfluenzaAsthmaARDSMSOFEclampsiaARF FibrosisScarAdhesion

  2. Dr. Hans Selye 1907-1982

  3. Fundamentals of Stress Theory • DNA + Stress Mechanism + embryological development? • Capillary Gate Theory ? • Clot formation? • Unified Tissue Repair Theory? • Coagulation Cascade • Mechanisms can now be described for all these old theories!! • It is the function of science to discover the existence of a general reign of order in nature and to find the causes governing this order.

  4. Factor VIII: The Odd Couple Von Willebrand’s Factor Vascular Endothelium Inert Fluctuates with Nervous activity Gigantic molecule Factor VIIIC liver Labile enzyme Generates Insoluble Fibrin Gigantic molecule

  5. Capillary Gate Theory Coagulation Cascade Tissue Repair Theory Autonomic Nervous System Vascular Endothelium Stress Repair Mechanism

  6. Autonomic Nervous System The Coagulation Cascade Capillary Gate Component Tissue Repair Component Soluble Fibrin Insoluble Fibrin

  7. The Universal Theory of Medicine of Hans Selye The Stress Repair Mechanism (SRM) COGNITIVE PATHWAY Visual, OlfactoryAuditory, Tactile Cerebral Cortex HPA Axis CAPILLARY GATE COMPONENTStressful StimuliIntravascularNeurons Pathways TISSUE REPAIR COMPONENT Surgery Trauma BurnsSepsisRadiationChemicalsToxins Anesthesia EmotionalMechanisms StressfulForcesExtravascularTissue Disruption EpinephrineNorepinephrineCortisol Hypothalamus Pain SYMPATHETIC Internuncial Nociception VASCULARENDOTHELIUM PARASYMPATHETIC Krebs Cycle Spinal Cord Tissue Factor Pathway InhibitorATIIIProtein C Insulin NitricOxide ThrombinAmplificationFactor IX Peripheral Nerves ATP Ca+ ThrombinAcceleration Analgesia Thrombin Activation TISSUE FACTOR PAI TPA Factor VII THROMBIN Factor VIIIC VON WILLIBRAND FACTOR PeripheralReceptors TAFI FIBRINOGEN Factor X Sensory Stressors FibrinSplit Products Insoluble Fibrin SOLUBLEFIBRIN Factor XIII SPINAL PATHWAY Fibronectin Vitronectin TISSUEREPAIR COAGULATION PlateletsInflammationChemotaxisMitosis SYSTOLICTURBULENTRESISTANCE PusScabsCastsExudates Abscesses CAPILLARYFLOW CAPILLARYHEMOSTASIS SYSTOLICLAMINARFLOW TemperatureCatabolismFeverImmune CellsEndotheliumOsteoblastsMyoblastsFibroblastsCollagen ImmuneProteins MetabolismAngiogenesisChemokinesCytokinesProstaglandins Malignancy Apoptosis HyperviscosityHypercoagulableFlow ResistanceIncreased SWR Cardiac WorkHypertensionDecreased CO Atherosclerosis Optimal ViscosityNormocoagulableFlow FacilitationDecreased SVRCardiac RestHypertensionIncreased COHealth & Longevity Tissue PerfusionHyperoxemiaOrgan ActivityDecreased SVROrgan PreservationHypotensionIncreased CODecreased HR Tissue IschemiaHypoxemiaOrgan QuiescenceIncreased SWROrgan StressHypertensionDecreased COIncreased HR BoneMuscle PneumoniaInfluenzaAsthmaARDSMSOFEclampsiaARF FibrosisScarAdhesion

  8. The End

  9. Dr. Johannes Rhodin 1922-2004

  10. Oswald Avery 1877-1955

  11. Francis Crick 1916-2004James Watson 1928-?

  12. The Vascular Endothelium TF SNS TF VWF PNS NO TF

  13. Thrombin: The Universal Enzyme of Energy Transformation • Transforms ATP into cell and enzyme effects • Requires Ca+ • Parathyroid glands regulate Ca+ to optimize thrombin activity • Energizes all tissue repair activities • Converts fibrinogen into soluble and insoluble fibrin • Clot formation, inflammation, mitosis, metabolism, angiogenesis & all other aspects of tissue repair • Chemokines, cytokines, prostaglandins for cell communications that coordinate the stages of tissue repair • Thrombin elevations cause malignancy • Thrombin declines trigger apoptosis • Vascular Endothelium regulates thrombin in healthy tissues • Red clot governs thrombin levels in healing tissues

  14. Soluble Fibrin: The Universal Protein of Tissue Repair

  15. Insoluble Fibrin: The Universal Polymer of Hemostasis

  16. The Universal Theory of Medicine of Hans Selye The Stress Repair Mechanism (SRM) COGNITIVE PATHWAY Visual, OlfactoryAuditory, Tactile Cerebral Cortex HPA Axis CAPILLARY GATE COMPONENTStressful StimuliIntravascularNeurons Pathways TISSUE REPAIR COMPONENT Surgery Trauma BurnsSepsisRadiationChemicalsToxins Anesthesia EmotionalMechanisms StressfulForcesExtravascularTissue Disruption EpinephrineNorepinephrineCortisol Hypothalamus Pain SYMPATHETIC Internuncial Nociception VASCULARENDOTHELIUM PARASYMPATHETIC Krebs Cycle Spinal Cord Tissue Factor Pathway InhibitorATIIIProtein C Insulin NitricOxide ThrombinAmplificationFactor IX Peripheral Nerves ATP Ca+ ThrombinAcceleration Analgesia Thrombin Activation TISSUE FACTOR PAI TPA Factor VII THROMBIN Factor VIIIC VON WILLIBRAND FACTOR PeripheralReceptors TAFI FIBRONIGEN Factor X Sensory Stressors FibrinSplit Products Insoluble Fibrin SOLUBLEFIBRIN Factor XIII SPINAL PATHWAY Fibronectin Vitronectin TISSUEREPAIR COAGULATION PlateletsInflammationChemotaxisMitosis SYSTOLICTURBULENTRESISTANCE PusScabsCastsExudates Abscesses CAPILLARYFLOW CAPILLARYHEMOSTASIS SYSTOLICLAMINARFLOW TemperatureCatabolismFeverImmune CellsEndotheliumOsteoblastsMyoblastsFibroblastsCollagen ImmuneProteins MetabolismAngiogenesisChemokinesCytokinesProstaglandins Malignancy Apoptosis HyperviscosityHypercoagulableFlow ResistanceIncreased SWR Cardiac WorkHypertensionDecreased CO Atherosclerosis Optimal ViscosityNormocoagulableFlow FacilitationDecreased SVRCardiac RestHypertensionIncreased COHealth & Longevity Tissue PerfusionHyperoxemiaOrgan ActivityDecreased SVROrgan PreservationHypotensionIncreased CODecreased HR Tissue IschemiaHypoxemiaOrgan QuiescenceIncreased SWROrgan StressHypertensionDecreased COIncreased HR BoneMuscle PneumoniaInfluenzaAsthmaARDSMSOFEclampsiaARF FibrosisScarAdhesion

  17. Charles Atlas or 90lb Weakling?

  18. Blood Acceleration & Turbulence Systolic Acceleration Diastolic Deceleration Diastolic Turbulence

  19. Pipe Flow Turbulence Lateral Forces Fast Faster Fastest

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