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Fibrinolysis is the break-down of blood clots, which is a crucial part of wound healing. If fibrinolysis is not regulated properly it may lead to numerous different diseases. View this PPT to know moreu2026
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Fibrinolysis is the break-down of blood clots, which is a crucial part of wound healing. If fibrinolysis is not regulated properly it may lead to numerous different diseases.
Fibrin and blood clots * A blood clot (Thrombus) is made up of aggregated platelets, red blood cells, and a mesh of cross-linked fibrin proteins. * A thrombus naturally occurs as a response to an injury, as a means to prevent bleeding.
What is Fibrinogen? It is a soluble protein that circulates in the blood at relatively small concentrations and is comprised of three separate polypeptide chains (Aα, Bβ, and γ) that are linked by disulfide bonds.
The role of fibrinolysis in disease * Dysregulation and faults with the fibrin/fibrinogen proteins can lead to a multitude of disorders relating to bleeding and clot formation. * Hyperfibrinolysis causes excessive bleeding.
Treatment * The treatment of fibrinolysis disorders varies by type and cause. * Disorders of impaired clot formation and structure can be treated usinghemostatic treatments.
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