1 / 20

Status of the optimized ClearPET  Neuro Scanner:

Status of the optimized ClearPET  Neuro Scanner:. Maryam Khodaverdi, H. Larue, C.Parl, U.Pietrzyk, M.Streun, S. Weber, Karl Ziemons Central Institute for Electronics, Forschungszentrum Jülich Member of Crystal Clear Collaboration. EuroMedim, Marseille May 10, 2006. desire :

jstapleton
Download Presentation

Status of the optimized ClearPET  Neuro Scanner:

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Status of the optimized ClearPETNeuro Scanner: Maryam Khodaverdi, H. Larue, C.Parl, U.Pietrzyk, M.Streun, S. Weber, Karl Ziemons Central Institute for Electronics, Forschungszentrum JülichMember of Crystal Clear Collaboration EuroMedim, Marseille May 10, 2006

  2. desire : high performance small animal PET Birth of the ClearPET Project flexible FOV high sensitivity high resolution for : international network CCC joint development of several dual-layer-phoswich-PET scanners The ClearPET Neuro Scanner - K.Ziemons

  3. ClearPET Prototypes ClearPET Rodent(VUB & Hosp. Gent) ClearPET prototype(Lausanne now Marseille) ClearPET petite(Samsung Med. C., Seoul) The ClearPET Neuro Scanner - K.Ziemons

  4. ClearPET™ Neuro Scanner @ Institute of Medicine, Forschungszentrum Jülich The ClearPET Neuro Scanner - K.Ziemons

  5. ClearPET™ Neuro Scanner • flexible ring diameter: 130 mm - 300 mm • gantry rotation: > 360° • gantry tilt: 0°- 90° • adjustable transversal FOV • axial FOV: 110 mm • flexible animal bed • Animal bed & animal chair The ClearPET Neuro Scanner - K.Ziemons

  6. improved crystal-PMT coupling Compensation of LSO-LuYAP light output increase of sensitivity due to consideration of inter-crystal-scattering Geometrical adjustment equidistant sampling automatic calibration procedure modification of the electronics for continuous operation 1st Optimization Phase in 2005 The ClearPET Neuro Scanner - K.Ziemons

  7. ClearPET™ Detector Blocks: • multi-channel photomultiplier tube (7600M64, Hamamatsu) • dual layer phoswich matrices: 8×8 LSO & LuYAP • each crystal element: 2.0×2.0×10mm3 • masks to avoid cross talk and equalise PM pixel response Old design New design The ClearPET Neuro Scanner - K.Ziemons

  8. ClearPET™ System Setup: LSO & LuYAP experimental spectra 3 mm  13 mm LSO  LuYAP PMT The ClearPET Neuro Scanner - K.Ziemons

  9. New Arrangement of Detector Blocks & Modules Old design New design 1/4 PM pitching distance in-line PM pitching distance==> equidistant sampling The ClearPET Neuro Scanner - K.Ziemons

  10. Calibration Procedure of a Detector Block  LSO  LuYAP The ClearPET Neuro Scanner - K.Ziemons

  11. Sensitivity with & without LuYAP readout • 0.25mm Na-source • 60s measurement w/o rotation • 5mm axial steps (FOV= 0-110mm) • 10ns coin.- window • 250keV E-threshold  system peak sensitivity ≈ 3.5 % +/- 0.2%(sys) The ClearPET Neuro Scanner - K.Ziemons

  12. Spatial Resolution Reconstructed point source by 3D reprojection algorithmimplemented in STIR 0,575mm binsize  RFWHM(center) = 1.3mm The ClearPET Neuro Scanner - K.Ziemons

  13. Spatial Resolution  in progress The ClearPET Neuro Scanner - K.Ziemons

  14. Derenzo Phantom • Ø 40mm, 1.0 - 2.0 mm rods • ~ 0.5mCi, 18F • 360° rotation, 1°/step • 6min actual scan time • 3D OSEM with geometric and detector efficiency correction 1.4mm 1.6mm 1.0mm 2.0mm The ClearPET Neuro Scanner - K.Ziemons

  15. FDG - Rat Scan • 400g rat • 0.5mCi FDG • Scan 30min after injection • 24min scan time • 3D OSEM w geometric and detector efficiency correction The ClearPET Neuro Scanner - K.Ziemons

  16. FDG - Rat Scan 3D OSEM with geometric and detector efficiency The ClearPET Neuro Scanner - K.Ziemons

  17. Summary of the ClearPET Neuro Properties • - Time resolution: 5.5 ns FWHM • Spatial resolution (center): 1.3mm FWHM • System peak sensitivity ≈ 3.5%+/-0.2% (sys) • - Energy resolution: ≈ 28% • - Maximum rate: 9 Mcps single events • - Dead time: 36 ns The ClearPET Neuro Scanner - K.Ziemons

  18. The ClearPET project resulted in small animal PET systems that compare well with commercial devices. There is ample room to improve it without fundamentally changing the design combined multi-modality option: µPET / µCTµPET / MRI (simultaneously) --> BrainPET APD (semiconductor detector) version is in progress Conclusion The ClearPET Neuro Scanner - K.Ziemons

  19. FZ-Juelich G. BRANDENBURG M.FLEISCHER L. FUß B. GUNDLICH M. KHODAVERDI P.KIRCHNER H. LARUE P. MUSMANN C. PARL U. PIETRZYK J. SCHMITZ M. STREUN S. WEBER K. ZIEMONS SEOUL Y. CHOI J.H. JUNG T.Y. SONG ClearPET Project Team • IPHE, Lausanne • J.-F. LAUDE • Ch. MOREL • J.-B. MOSSET • M. REY • L. SIMON • J.-M. VIEIRA • CERN • E.AUFFRAY • P. LECOQ • J. TRUMMER • INP-Minsk • A.FEDOROV • M.KORJIK • UNI. Gent • Y.D‘ASSELER • S. STAELENS • R. VAN HOLEN • IPNL-Lyon • M. BOUTEMEUR • C. DUJARDIN • M. JANIER • G. LAGERON • C. LATRIZIEN • Ch. PEDRINI • D. SAPPEY-MARINIER • VUB-Brussels • P. BRUYNDONCKX • M. KRIEGUER • O. DEVROEDE • C. LEMAITRE • C. LEONARD • S. TAVERNIER • E. WIEERS • M. WISNIEWSKA • D. WISNIEWSKI • Y. WU • IPR- Ashtarak • A. PETROSIAN And all other members of the CCC The ClearPET Neuro Scanner - K.Ziemons

  20. many thanks to ALL my colleagues&the whole CCC

More Related