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Exploring Identity: From Molecules to Individuals

This interdisciplinary event aims to explore the determinants of identity at various scales of analysis, bringing together biologists, physicists, mathematicians, and social scientists. Topics include epigenetic mechanisms, environmental influences, disease consequences, and societal impact.

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Exploring Identity: From Molecules to Individuals

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  1. Journées d'information et de prospective du pôle SET

  2. groupe B: Science et technologie des molécules aux matériaux innovants groupe A: Science et technologie de l’observation et de la modélisation groupe C: Sciences fondamentales  et technologies pour le vivant Journées d'information et de prospective du pôle SET

  3. Journées d'information et de prospective du pôle SET

  4. The benefits of an interdisciplinary approach

  5. groupe C: Sciences fondamentales  et technologies pour le vivant • Jonathan WEITZMAN • PI, team Plasticity of Cellular Phenotypes

  6. How do intracellular parasites Theileria transform host leukocytes?

  7. groupe C: Sciences fondamentales  et technologies pour le vivant • Jonathan WEITZMAN • PI, team Plasticity of Cellular Phenotypes • UMR Epigenetics and Cell Fate

  8. exploring the epigenetic landscape Conrad Waddington

  9. exploring the epigenetic landscape Conrad Waddington

  10. Pierre- Antoine Jonathan Valérie Claire R Slimane Claire F Bertrand Sophie

  11. 1 Epigenetic mechanisms 2 Environment, Development and Disease

  12. Contrat d’établissement 2014-2019 1 2

  13. Technology Platforms Bâtiment Lamarck • L3 Lentiviral & Retroviral Production • Functional Epigenomics 534 531 527/529 Christophe Huret IGE UPD Laure Ferry AI UPD

  14. groupe C: Sciences fondamentales  et technologies pour le vivant • Jonathan WEITZMAN • PI, team Plasticity of Cellular Phenotypes • UMR Epigenetics and Cell Fate • DHU Protect Hop Robert Debré • LIA EpigenoStem

  15. EPIGENO-STEM LIA Laboratoire International Associé • Exchange of material and regents hESC, IPS • Exchange of expertise Methylation, non-coding RNA, High throughput Sequencing • Exchange of students and researchers Marc LALANDE

  16. groupe C: Sciences fondamentales  et technologies pour le vivant • Jonathan WEITZMAN • PI, team Plasticity of Cellular Phenotypes • UMR Epigenetics and Cell Fate • DHU Protect Hop Robert Debré • LIA EpigenoStem • LabexWho Am I?

  17. Laboratoire d’Excellence Who Am I? Exploring identity: from molecules to individuals Exploring the determinants of identity - diverse scales of analysis: chemical, molecular, cellular and social. - an inter-disciplinary approach bringing together biologists, physicists, mathematicians and social scientists to address common fundamental questions. Financed by the Investments for the Future program ‘Laboratoire d’Excellence’ call 2: March 2012-December 2019 Who Am I? is lead by Catherine DARGEMONT and Jonathan WEITZMAN coordinated by the Université Sorbonne Paris Cité managed by the Université Paris Diderot. Project manager: Pauline ANDREU Total budget: 11 MEuros

  18. Proposal – Partnership MolecularPathology and Virology Unit (PVM)CNRS UMR7212, INSERM U944 Epigenetics and Cell Fate Unit (EDC)CNRS UMR7216 Institut Jacques Monod (IJM)CNRS UMR7592 ComplexMatter and Systems (MSC)CNRS UMR7057 Center for Research on Psychoanalysis, Medecine and Society (CRPMS) EAD3522 Institut Cochin (IC) CNRS UMR8104, INSERM U1016 TaMaRa INSERM U1001 Center for Research on Meaning, Ethics and Society CNRS UMR8137 Associated teams J. Salamero (Institut Curie, INRIA & France Bio-Imaging) J. Gayon (IHPST, Paris 1-ENS-CNRS)

  19. Proposal – Research axes WHO AM I? ExploringIdentity frommolecules to individuals What are the systems (genetic and epigenetic) that dictate the establishment of different cellular states and ensure the transmission of identity to subsequent generations? What are the molecular mechanisms that participate in the maintenance and integrity of molecular and cellular identities? Establishment & Transmission Maintenance & Integrity (Loss of) Identity What are the consequences of these systems to evolution in terms of cumulative changes in identity over time and throughout populations? What is the impact of environment on defining identities and how are identities perceived externally? Evolution Environment & Perception What are the pathological consequences of deregulation of these mechanisms leading to a loss of identity and how might they be controlled to combat disease? TaMaRa EDC PVM MSC IJM CRPMS IC GV

  20. 2016-2019-Perspectives • Who Am I? strategy validation • Inter-disciplinary and humanities integration • Emergence of strong scientific themes • Emergence of visible research clusters • Structuring effect and significant impact on its ecosystems • Financial pull effect Economic Impact > Survey and encourage technology transfer > Develop industrial partnerships Scientific Development > Inter-disciplinarity > International development > Structure the labex scientific themes to maximize the labex visibility Impact on Society > Create new lay public events for diverse audience > Develop the school debates program > Science & Culture projects > Increase the labex visibility Mentoring and Career Development > Maximize young researchers employability

  21. groupe C: Sciences fondamentales  et technologies pour le vivant • Jonathan WEITZMAN • PI, team Plasticity of Cellular Phenotypes • UMR Epigenetics and Cell Fate • DHU Protect Hop Robert Debré • LIA EpigenoStem • LabexWho Am I? • Teaching and Training

  22. 2012-2015 – Inter-disciplinary Teaching & Training: a Continuum Graduate Program > Annual call for proposals > 14 PhD students engaged in collaborative and inter-disciplinary projects Transdisciplinary Post-Doc Program > Annual call for proposals > 16 post-docs recruited Identity Master Module > European Master in Genetics > To be launched in 2016 Inter-disciplinary Pre-Doc Training > Fund a year of training in a new discipline > Pilot launched in 2014 Mentoring and Career Development > Maximize young researchers employability > Workshop on career in science (April 8, 2016) Transition Post-Doc > Fund an intermediate phase between the PhD and a post-doc > Annual call for proposals > 9 PhDs recruited Identity for all _ Who Am I? class at Paris Diderot Open University

  23. groupe C: Sciences fondamentales  et technologies pour le vivant • Jonathan WEITZMAN • PI, team Plasticity of Cellular Phenotypes • UMR Epigenetics and Cell Fate • DHU Protect Hop Robert Debré • LIA EpigenoStem • LabexWho Am I? • Teaching and Training • Magistère de Génétique • Académie Vivante

  24. L’académie vivante • TP : cours de travaux pratiques • Séminaire« laboratoire d’études de libre-pensée » • Atelier transdisciplinaire • Revue transdisciplinaire annuelle Melissa Dubbin and Aaron S. Davidson

  25. Journées d'information et de prospective du pôle SET

  26. The benefits of an interdisciplinary approach

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