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Metabolomics: An Untapped Frontier

Metabolomics: An Untapped Frontier. Since the completion of the human gene sequence, the focus has shifted on the function of sequenced genes and their roles in disease detection and treatment. Proteomics along with other ‘omics’ are

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Metabolomics: An Untapped Frontier

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  1. Metabolomics: An Untapped Frontier • Since the completion of the human gene sequence, • the focus has shifted on the function of sequenced • genes and their roles in disease detection and • treatment. • Proteomics along with other ‘omics’ are • revolutionizing our approaches to disease detection. • Cancer detection remains a high priority for NCI and • numerous initiatives on proteomics, nanotechnolgy • have been launched.

  2. Metabolomics Workshop Sudhir Srivastava, Ph.D., MPH Chief, Cancer Biomarkers Research Group Division of Cancer Prevention National Cancer Institute, NIH

  3. This is a Century of Small Molecules Then Now Aptamers DNA Micro RNA RNA Proteomics, Glycomics Metabolomics Protein

  4. The Wonders of Small Molecules • Structurally amenable to targeting by drugs • Likely to shed a lot of information on patho-physiological • state of cells • Likely to be less complex than proteins • Limited in numbers (around 3000 ‘functional’ • metabolites (Beecher)

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