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The Independent Cancer Patients Voice a warm welcome to Leeds!

The Independent Cancer Patients Voice a warm welcome to Leeds!. Programme. 11.15 Collection & use of tissue and its value to cell biology Val Speirs, Debbie Holliday, Laura Smith, Aidan Hindley 13.00 Lunch with Dave Ardon, Chair NCRI Consumer Liaison Group

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The Independent Cancer Patients Voice a warm welcome to Leeds!

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  1. The Independent Cancer Patients Voice a warm welcome to Leeds!

  2. Programme 11.15 Collection & use of tissue and its value to cell biology Val Speirs, Debbie Holliday, Laura Smith, Aidan Hindley 13.00 Lunch with Dave Ardon, Chair NCRI Consumer Liaison Group 14.00 Bone related issues in breast cancer treatment Rob Coleman 15.00 Consultation on measures of emotional distress Lucy Ziegler 16.00 Tea & ICPV discussion 16.30 Different methods of breast reconstruction Raj Achuthan 17.30 Lab tour Steven Pollock & Michele Cummings

  3. Section of Pathology and Tumour Biology Collection and use of tissue and its value to cell biology Valerie Speirs Deborah Holliday Laura Smith

  4. Breast cancer:One disease or many?

  5. If it looks different, it is different

  6. 310

  7. Frequency of chromosomal aberrations in breast cancer Grade I Grade II Roylance et al., Cancer Res 1999

  8. Breast cancer is heterogeneous: One size does not fit all!

  9. How can we model breast cancer in the lab? • Cell lines • Animal models • Human clinical material

  10. Pros ease of use homogeneous easily replaced Cons origin genetic drift reproducibility Cell lines

  11. Burdall et al., Breast Cancer Res, 2003

  12. Separate MCF-7 strains from different laboratories Morphology similar in all cases Growth rate variable Karyotype (CGH/SKY) variable ER/PR content variable Case study: MCF-7

  13. Breast cancer is a complex disease which is not easily modelled in animals Concerns over the validity of animal models breast tumours taken from animal experiments do not accurately represent human breast cancers in their appearance Ethical pressure on scientists 3Rs Animal models

  14. Pros established directly from tumours more representative models Biologically Clinically Cons difficult to establish slow doubling times contamination by fibroblasts/normal epithelial cells Ethical issues (HTA) Tissue access Primary cultures derived from human material

  15. Breast Cancer Campaign • Mission To beat breast cancer by funding innovative world-class research to understand how breast cancer develops, leading to improved diagnosis, treatment, prevention and cure

  16. Background to Breast Cancer Campaign • Breast Cancer Campaign is the only charity that specialises in funding independent breast cancer research throughout the UK • Supports high quality research (basic and clinical) in universities, medical schools/teaching hospitals and research institutes in the UK and ROI

  17. Since 1988 BCC have supported: • 183 grants • £18.5 million • Currently funds >100 research projects throughout the UK/ROI worth > £13.5M • In Yorkshire, Campaign has supported • 11 grants • £1.25 million

  18. Breast Cancer Campaign • http://www.truveo.com/breast-cancer-campaign%E2%80%99s-research/id/3900128381

  19. Breast Cancer Campaign Gap Analysis • One-day meeting convened in London on 2 November 2006 • 56 of the UK’s most influential breast cancer experts identified the key research gaps and priorities for the greatest potential impact on patients

  20. Format • Before, during and after the meeting, groups in seven key research areas participated in cycles of presentation, literature review and discussion

  21. Groups • Genetics • Initiation • Progression • Therapies and targets • Disease markers • Prevention • Psychosocial aspects

  22. Questions posed • What do we know? • What are the gaps? • Problems • Translational implications • Recommendations

  23. Summary papers were prepared by each group and collated into a position paper highlighting the research gaps, with recommendations for action

  24. Highly accessed

  25. Mission Statement To provide, in partnership with BCC, highly specialised breast cancer related biomaterials to support cutting-edge translational research for the benefit of the patient

  26. Why is the tissue bank so important? • Access to standardised, well annotated human breast tissue will help identify the causes of breast cancer, develop new treatments, identify genes associated with breast cancer and, most importantly, accelerate research from the laboratory to the clinic

  27. Questions?

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