The Future of Brain Based Health

1. The Future of Brain Based Health

3. Features and Benefits • FDA Cleared • Normalizes Neurochemistry • Safe and non-invasive • “Resets” Mid-Brain • Restores Brain Function • Reduce levels of Anxiety and Depression • Enhances ability to sleep longer and/or deeper • Enhances ability to communicate with loved ones and co-workers

4. Need for Treatment If you suffer from anxiety, depression and insomnia (ADI) or have issues with substance or alcohol abuse or dependency caused by ADI… You are not alone!

5. Need for Treatment Depression • 41.9 million Americans suffer from Depression Anxiety • 40 million Americans suffer from Anxiety Insomnia • 60 million Americans suffer from Insomnia You are NOT alone!

6. U.S. population suffering from Chart is in millions *Many that suffer from Post-Traumatic Stress Disorder (PTSD) also exhibit symptoms of depression, anxiety and insomnia

7. Need for Treatment • There is a very close relationship between substance abuse and depression* • Substance abuse and depression frequently co-occur in adolescents** * abcnews.go.com/Health/DepressionScreening/story?id=4355978 ** www.sciencedirect.com/science/article/pii/S0749379706002431

8. Chart is in millions U.S. population affected by substance abuse

9. Potential Solutions • Nexalin Treatments (safe & effective) • Pharmaceutical Solutions (warning labels) • Electroshock Therapy (potential loss of memory… scary) • Medical Devices (warning labels) • Live with the suffering

10. Why Nexalin • Nexalin is Effective • Nexalin is Safe • Nexalin is Long lasting 10 to 15 restful Nexalin Treatments in a comfortable chair offers long lasting and effective benefits. Nexalin has been proven to be as safe as placebos.

11. Nexalin Treatment Programs • 1 per day for 10 to 15 days • 2 per day for 5 days (in study stage) • 3 per day for 5 days (in study stage) • 10 treatments over 3 days (3… 4… 3) (in study stage) • 5 per day for 3 days (in study stage) • Recent treatments have shown multiple treatments in a single day offer the same immediate results as single daily treatments

12. Present Pharmaceutical Treatments are Problematic • Benzodiazepines, often prescribed for anxiety account for 32% of drug related visits to the emergency rooms* • Self-medication with alcohol ranged from 7.9% to 35.6% in those with anxiety*** • In a nationally representative survey, almost one-quarter of individuals with mood disorders (24.1%) used alcohol or drugs to relieve symptoms**** U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES (2004). "Drug Abuse Warning Network, 2004 *** www.ncbi.nlm.nih.gov/pubmed/17102705 **** www.ncbi.nlm.nih.gov/pubmed/19004504

13. Drugs for Anxiety and Depression • Selective Serotonin Reuptake Inhibitors (SSRIs) • Serotonin & Norepinephrine Reuptake Inhibitors (SNRIs) • Monoamine Oxidase Inhibitors (MAOIs) • Narcotics • Benzodiazepines • All have issues with tolerance, dependence and withdrawal • Some are addictive • Some have withdrawal problems

14. Pharmaceutical Side Effects • Many drugs warn of potential side effects that range from mild to severe to potentially fatal • It is reported that prescription drug abuse is more deadly than heroin and cocaine combined • About 6.1 million people abuse prescription pills • Overdose deaths have at least doubled during the past decade www.csmonitor.com/USA/Society/2013/1007/Prescription-drug-abuse-now-more-deadly-than-heroin-cocaine-combined

15. Medical Device Options • Electro Convulsive Therapy (ECT) • Transcranial Magnetic Stimulation (TMS) • Deep Brain Stimulation (DBS) • Vagus Nerve Stimulation (VNS)

16. Electroconvulsive Therapy (ECT) • ECT is a procedure in which electric currents are passed through the brain, intentionally triggering a brief seizure. Requires general anesthesia. • Potential side effects include confusion, memory loss, nausea, vomiting, headache, jaw pain, muscle ache or muscle spasm. www.mayoclinic.com/health/electroconvulsive-therapy/MY00129

17. (ECT) Additional Side Effects • Medical complications such as heart rate and blood pressure increase may also occur, which may lead to serious heart problems.* • The treatment costs $1,000 to $2,500 per session, and typically involves from 6 to 12 sessions. Total cost can range from $6,000 to $30,000.** * www.mayoclinic.com/health/electroconvulsive-therapy/MY00129 ** www.nytimes.com/2011/01/24/business/24shock.html?pagewanted=all&_r=0

18. Transcranial Magnetic Stimulation (TMS) • TMS uses magnetic fields to stimulate nerve cells in the brain.* • A large electromagnetic coil is placed against the scalp near the forehead.* Members of the FDA panel expressed doubts that the machine helps depressed patients or provides any advantage over placebo treatment.** * www.mayoclinic.com/health/transcranial-magnetic-stimulation/MY00185 ** www.webmd.com/depression/news/20070129/device-for-depression-criticized

19. (TMS) Additional Side Effects • Common side effects can include headache, scalp discomfort, tingling, spasms or twitching of facial muscles, lightheadedness* • Uncommon side effects include seizures, mania and hearing loss* • Long term side effects are not known* • Cost for patients: $8,000-12,000** * www.mayoclinic.com/health/transcranial-magnetic-stimulation/MY00185 * * www.usatoday.com/story/news/2012/11/30/magnets-zap-depression/1738621/

20. Deep Brain Stimulation (DBS) • Requires major surgery while the patient is awake. Two holes are drilled in the skull. Two electrodes are implanted into the brain. They produce electrical impulses controlled by a device implanted under the skin in the chest.* • Warnings include surgical risks, paralysis, coma, and/or death. Leakage of the fluid surrounding the brain, seizures, infection and allergic response to the implanted material.** * www.mayoclinic.com/health/deep-brain-stimulation/MY00184 ** www.medtronic.com/downloadablefiles/220716003.pdf

21. (DBS) Additional Side Effects • Potential side effects after surgery include tingling sensation, speech problems, Vision problems, dizziness, facial and limb muscle weakness or partial paralysis. Jolting or shocking sensations.* • You may also experience pain, lack of healing or infection. The brain’s stimulation system parts may wear through your skin. And finally you may need additional surgeries to re-adjust the location (2.7 on average).* • Cost for patients is about $50,000 for initial surgery. $10,000 or more for additional surgeries every few years to maintain the device, change the settings, and to replace the battery** * www.medtronic.com/downloadablefiles/220716003.pdf ** theconversation.com/deep-brain-stimulation-the-hidden-challenges-of-a-technological-fix-14395

22. Vagus Nerve Stimulation (VNS) • A procedure that stimulates the vagus nerve with electrical impulses. A device is surgically implanted in the chest, and a wire connects it to the left vagus nerve. • Surgical complications can include pain, infection, incision scarring, difficulty swallowing and vocal cord paralysis. www.mayoclinic.com/health/vagus-nerve-stimulation/MY00183

23. (VNS) Additional Side Effects • Side effects can include voice changes, hoarseness, throat pain, cough, headache, chest pain, breathing problems, difficulty swallowing, abdominal pain or nausea, tingling or prickling of the skin.* • Total cost can range from $21,000 to $34,000 for generator, electrode, surgical and hospital costs.** * www.mayoclinic.com/health/vagus-nerve-stimulation/MY00183 ** www.psychiatrictimes.com/articles/study-expands-vagus-nerve-stimulation-depression

24. Again, Why Nexalin?

25. Again, Why Nexalin? • Patients treated experienced an average improvement of 81% to 85% for their primary and secondary symptoms • 90% of patients treated received a benefit

26. Why Nexalin? Almost to restful Nexalin Technician #1. Seats Client in Comfortable Chair 2. Puts one contact pad on the forehead and one behind each ear. #3. Pushes the start button. Nexalin is simple to administer

27. How It Works • Nexalin’s unique patented technology covers all three… frequency, wave form, and methodology. • Nexalin delivers a tri-symmetrical transcranial electrical stimulation at a frequency of 77.5 Hz.

28. How It Works • Laboratory and clinical evidence suggest that Nexalin affects the hypothalamus • The hypothalamus’ main function is to maintain homeostasis • The hypothalamus maintains normal levels of serotonin, beta-endorphins, neuropeptides, neurotransmitters and neuromodulators

29. Clinical Results

30. Clinical Results • The Beck Depression Inventory is used for measuring the severity of depression. • The Hamilton Depression Rating Scale or HAM-Dis often used as an endpoint in depression trials. • The Hamilton Anxiety Scale or HAM-A is an assessment test for anxiety.

31. Nexalin Clinical Trial Results Hamilton Depression Rating Beck’s Depression Inventory Developed for measuring the severity of endpoint depression Used for measuring the severity of depression in trials

32. Clinical Safety Unpublished Report Kalaco Scientific Inc.

33. Summary of Patient Benefits • Nexalin is a safe, cost-effective treatment for anxiety, depression and insomnia • Nexalin has an effective success rate of 80-90% • Nexalin has a side effect profile similar to placebo which should be exciting for all patients and those that love them

34. Anyone you know suffering directly from Depression, Anxiety, Insomnia or indirectly because of alcohol or substance abuse needs to know about Nexalin

35. Learn More Additional information is available on the web at www.Nexalin.com Or www.yourname.nexalin.com or by calling Nexalin Treatment Center: Your Phone # Address