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BAP1 and involvement in Mesothelioma, CMML, Uveal (eye) melanoma

BAP1 and involvement in Mesothelioma, CMML, Uveal (eye) melanoma. BAP1 is a de- ubiquitinating enzyme (DUB) found in the nucleus. BAP1 has many roles within the cell. Developmental problems in mice. BAP1 mutations are found in many human cancers. Breast Lung Skin Kidney Prostate Ovary

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BAP1 and involvement in Mesothelioma, CMML, Uveal (eye) melanoma

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  1. BAP1 and involvement in Mesothelioma, CMML, Uveal (eye) melanoma

  2. BAP1 is a de-ubiquitinating enzyme (DUB) found in the nucleus

  3. BAP1 has many roles within the cell

  4. Developmental problems in mice

  5. BAP1 mutations are found in many human cancers • Breast • Lung • Skin • Kidney • Prostate • Ovary • Colorectal • Pancreatic

  6. Hereditary BAP1 +/- predisposes humans to certain cancers  Mesothelioma • Leukemia (CMML)  Uveal Melanoma

  7. BAP1 KO Mice  Enlarged d spleens • Excess White Blood Cells Low Platelet dd and Red Blood d Cell Count

  8. Chronic Myelomonocytic Leukemia (CMML)

  9. Inhalation of asbestos fibers canlead to mesothelioma Surgery Chemotherapy Radiation

  10. Uveal melanomas can be treated with cutting-edge radiosurgery

  11. References • Dieckmann, K., Georg, D., Zehetmayer, M., Bogner, J., Georgopoulos, M., and Pötter, R. (2003). LINAC based stereotactic radiotherapy of uveal melanoma: 4 years clinical experience. Radiotherapy and Oncology, Volume 67, Issue 2, Pages 199–206 • Ladanyi, M., Zauderer, M., Krug, L., Ito, T., McMillan, R., Bott, M., and Giancotti, F. (2012). • New Strategies in Pleural Mesothelioma: BAP1 and NF2 as Novel Targets for Therapeutic Development and Risk Assessment. Clin Cancer Res ,vol. 18 no. 17 4485-4490 • Dey, A., Bakalarski, C. E., Wu, J., Phu, L., Katavolos, P., LaFave, L. M., . . . Lill, J. R. (2012). Loss of the tumor suppressor BAP1 causes myeloid transformation. Science (New York, N.Y.), 337(6101), 1541-1546. doi:10.1126/science.1221711 • White, A., & Harper, J. (2012). Emerging anatomy of the BAP1 tumor suppressor system. Science, 337(6101), 1463-1464. doi:10.1126/science.1228463 • Abdel-Wahab, O., & Dey, A. (2013). The ASXL-BAP1 axis: New factors in myelopoiesis, cancer and epigenetics. Leukemia, 27(1), 10-15. doi:10.1038/leu.2012.288 • Testa, J. R., Trusa, S., Hesdorffer, M., Nasu, M., Powers, A., Rivera, Z., . . . Pass, H. I. (2011). Germline BAP1 mutations predispose to malignant mesothelioma. Nature Genetics, 43(10), 1022-U140. doi:10.1038/ng.912 • www.asbestos.com • http://www.vidaza.com/patient/understanding-vidaza.aspx

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