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Chapter 10: DNA The Molecular Basis of Genetics

Chapter 10: DNA The Molecular Basis of Genetics. The flow of information:. 1. Storage. 2. Replication. 3. Expression. DNA as the Genetic Material. *1868 Friedrick Miescher. *1910 Phoebus Levene tetranucleotide hypothesis. *1927 Frederick Griffith transforming principle.

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Chapter 10: DNA The Molecular Basis of Genetics

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  1. Chapter 10: DNA The Molecular Basis of Genetics The flow of information: 1. Storage 2. Replication 3. Expression

  2. DNA as the Genetic Material *1868 FriedrickMiescher *1910 Phoebus Levene tetranucleotide hypothesis *1927 Frederick Griffith transforming principle *1944 Avery, MacLeod and McCarty *1952 Alfred Hershey and Martha Chase

  3. Evidence for DNA in Eukaryotes: Indirect evidence: *Distribution of DNA *Mutagenesis *RNA – genetic material in some viruses

  4. Nucleotide Structure: Pentose sugar

  5. Nucleotide Structure: Nitrogenous Bases

  6. Structural Analysis of DNA: *nucleoside *nucleotide

  7. Nucleic Acid Polarity *Top of molecule has free 5’-phosphate group This is the 5’ end *Bottom has a free 3’ hydroxyl group This is the 3’ end

  8. Base Composition: *1949-1953 Chargaff’s Rules

  9. Complementarity

  10. DNA Structure: *Early 1950’s Rosalind Franklin *1953 Watson and Crick *Linus Pauling

  11. S.R. Eddy (2001) Noncoding RNA genes and the modern RNA world, Nature Reviews Genetics, 2:919-929 RNA Structure: *Similar to DNA *Three major classes of RNA

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