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Achondroplasia : a dominant mutation of HGH (Human Growth Hormone) gene: aa – normal; AA – lethal; Aa – achondroplasic dwarf (“midget”). Figure 9.13. Figure 9.32. Friedrich Miescher. Gregor Mendel. H J Muller. Thomas Hunt Morgan. George Gaylord Simpson.
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Achondroplasia:a dominant mutation of HGH (Human Growth Hormone) gene: aa – normal; AA – lethal; Aa – achondroplasic dwarf (“midget”)
Friedrich Miescher Gregor Mendel
H J Muller Thomas Hunt Morgan George Gaylord Simpson
"Let me try to make crystal clear what is established beyond reasonable doubt, and what needs further study, about evolution. Evolution as a process that has always gone on in the history of the earth can be doubted only by those who are ignorant of the evidence or are resistant to evidence, owing to emotional blocks or to plain bigotry. By contrast, the mechanisms that bring evolution about certainly need study and clarification. There are no alternatives to evolution as history that can withstand critical examination. Yet we are constantly learning new and important facts about evolutionary mechanisms." - Theodosius Dobzhansky "Nothing in Biology Makes Sense Except in the Light of Evolution", American Biology Teacher vol.35 (March 1973)
Theodosius Dobzhansky (1900-1975) in a group photo in Kiev in 1924; he is seated second from the left at the front, in the great boots.
James Watson & Francis Crick 1953 – DNA structure Rosalind Franklin
TRANSCRIPTION (making RNA) and TRANSLATION (making protein) Figure 10.20
MUTATION: DNA, mRNA, protein Figure 10.21
G -> A: not a physical change but “typing error” in replication when DNA is being copied: A is included instead of G Figure 10.22 OVERSIMPLIFICATION! Please understand what really happens: not a physical removal of a nucleotide but a “typing error” in replication: a nucleotide is skipped or added when DNA is being copied