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Programmable and Autonomous Computing Machine Made of Biomolecules

This study presents a biomolecular computing machine made of biomolecules that can perform programmable and autonomous operations, using finite automaton principles. The machine integrates hardware components like Class IIS restriction nuclease FokI and T4 DNA ligase with software elements encoded in eight dsDNA molecules. The operation and experiment summary reveal the machine's efficiency, energy consumption rate, and computational complexity.

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Programmable and Autonomous Computing Machine Made of Biomolecules

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  1. Programmable and Autonomous Computing Machine Made of Biomolecules Y. Benenson, T.Paz-Elizur, E. Keinan, Z. Livneh and E. Shapiro Nature, v.414, 22 Nov. 2000, pp.430-434 Summarized by Lee, In-hee

  2. Introduction • Constructed finite automaton • Hardware • Class IIS restriction nuclease FokI • T4 DNA ligase • ATP • Software • Eight ds DNA molecules (transition molecules) • ds DNA encoding initial state and input • Two output detection molecules

  3. Operation

  4. Operation

  5. Experiment

  6. Summary • 109 transitions per second • Energy consumption rate 10-10 W • Complexity is bounded by number of non-palindromic sticky ends

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