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Limit of quantitation (LOQ) Limit of linearity (LOL)

Limit of quantitation (LOQ) Limit of linearity (LOL) Dynamic Range – Range where quantitative measurements can be made. -between LOQ and LOL. Selectivity – Degree to which the method is free from interference by other species contained in sample matrix. Chapter 5 Signals and Noise.

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Limit of quantitation (LOQ) Limit of linearity (LOL)

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  1. Limit of quantitation(LOQ) Limit of linearity (LOL) Dynamic Range – Range where quantitative measurements can be made. -between LOQ and LOL

  2. Selectivity – Degree to which the method is free from interference by other species contained in sample matrix.

  3. Chapter 5Signals and Noise

  4. Sources of Noise • Chemical • Instrumental (thermal/shot/flicker/environmental) Chemical Noise – Arises from many sources of uncontrolled variables that affect chemistry of the system. Instrument Noise -Thermal / shot / flicker / environmental

  5. Thermal Noise (Johnson Noise) -Caused by thermal agitation of electrons in electrical components. Shot Noise -Encountered when electrons (or charged particles) cross a junction. Flicker Noise (1/f ) -characterized by having magnitude that is inversely proportional to freq of signal

  6. Environmental Noise -Noise that arises from surroundings.

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