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Buruli Ulcer

Buruli Ulcer . Arwen Frick-Cheng Bio 402. What is Buruli Ulcer?. Infectious disease Characterized by the WHO as a Neglected Tropical Diseases (NTD) 14 NTD Widely disregarded by industrial nations. What is Buruli Ulcer?. Regions/People Affected. Tropical wetlands and rainforest

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Buruli Ulcer

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  1. Buruli Ulcer Arwen Frick-Cheng Bio 402

  2. What is Buruli Ulcer? • Infectious disease • Characterized by the WHO as a Neglected Tropical Diseases (NTD) • 14 NTD • Widely disregarded by industrial nations

  3. What is Buruli Ulcer?

  4. Regions/People Affected • Tropical wetlands and rainforest • Mainly: West and Central Africa • Associated with bodies of stagnant water • The immunocompromised • The poor • Children

  5. Causative Agent • Mycobacterium ulcerans • Related to Tuberculosis, Leprosy Colonies of Mycobacterium ulcerans. http://www.public.asu.edu/~shaydel/research_002buruli.html

  6. Identification of Bacteria • Acid Fast Stain • Selective Culture • Histopathology • PCR Acid-fast stain of Mycobacterium ulcerans. http://www.who.int/buruli/information/diagnosis/en/index14.html

  7. Symptoms • Long latent period • Usually on exposed body parts • Four stages

  8. Virulence Factor • Toxin: Mycolactone • Immunosupressant • Necrosis

  9. Treatment • Antibiotic • Rifampicin • Surgical removal/amputation • Vaccination (BCG) • Alternatives • Heat treatment • French Clay • Topical nitrogen oxides • Will slowly heal on its own

  10. Effects • Heavy scarring • Contracture of limbs • Blindness • secondary infections

  11. References • Neglected Diseases Caused By Bacterial Infections. M. Bechtle, S. Chen and T. Efferth. Current Medicinal Chemistry, 2010, 17, 42-60 • Laboratory diagnosis of Buruli ulcer disease. Marcus Beissner, Karl-Heinz Herbinger & Gisela Bretzel. Future Science Group • MycolactoneInhibits Monocyte Cytokine Production by a Posttranscriptional Mechanism.Rachel E. Simmonds et al. J. Immunol. 2009;182;2194-2202

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