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Keith Ng, Mark Butlin, and Alberto P. Avolio, J. Hypertens . 2012; (30)9: 1782-1790

Persistent effect of early, brief angiotensin-converting enzyme inhibition on segmental pressure dependency of aortic stiffness in spontaneously hypertensive rats. Study Design. Normotensive WKY Rats. Spontaneously Hypertensive Rats. 6 weeks. Perindopril 3 mg/kg/d. 10 weeks. 20 weeks.

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Keith Ng, Mark Butlin, and Alberto P. Avolio, J. Hypertens . 2012; (30)9: 1782-1790

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  1. Persistent effect of early, brief angiotensin-converting enzyme inhibition on segmental pressure dependencyof aortic stiffness in spontaneously hypertensive rats Study Design Normotensive WKY Rats Spontaneously Hypertensive Rats 6 weeks Perindopril 3 mg/kg/d 10 weeks 20 weeks Perindopril 3 mg/kg/d 24 weeks End of the Study 25 weeks SHR Untreated SHR (Tx)y SHR (Tx)o Non-treated Keith Ng, Mark Butlin, and Alberto P. Avolio, J. Hypertens. 2012; (30)9: 1782-1790

  2. Earlybriefperindopriltreatmentpreventshighblood pressure in spontaneouslyhypertensive rats Blood pressure at 25 weeks Pulse pressure at 25 weeks * * * * * * Keith Ng, Mark Butlin, and Alberto P. Avolio, J. Hypertens. 2012; (30)9: 1782-1790

  3. Early brief perindopril treatment protects against vascular wall stiffness Pulse Wave Velocity Analysis PWV-MAP Curves for all treatment groups plotted for the whole aorta or the thoracic aorta. Keith Ng, Mark Butlin, and Alberto P. Avolio, J. Hypertens. 2012; (30)9: 1782-1790

  4. Early brief perindopril treatment protects against vascular wall remodeling Aortic elastin content at 25 weeks Elastin/collagen ratio at 25 weeks * * * * Keith Ng, Mark Butlin, and Alberto P. Avolio, J. Hypertens. 2012; (30)9: 1782-1790

  5. Conclusions • Spontaneously hypertensive rats (SHR) do not develop high blood pressure at adulthood (25 weeks), even after treatment withdrawal, if they are treated early with perindopril (between 6 and 10 weeks of age) • Treatment with perindopril protected young SHR against arterial stiffness as indicated by their significantly lower PWV and aortic collagen content when compared with their late-treated counterparts • Aortic compliance was preserved with a higher elastin/collagen ratio and lower calcium content than in late-treated rats. Keith Ng, Mark Butlin, and Alberto P. Avolio, J. Hypertens. 2012; (30)9: 1782-1790

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